Details of the Drug Combinations

General Information of This Drug (ID: DMM61Y2)

Drug Name
BRL-15572   DMM61Y2
Synonyms BRL15572; BRL-15,572; BRL 15572
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

57 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + BRL-15572 DCHWB76 Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Amantadine + BRL-15572 DC6TARN Amantadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aprepitant + BRL-15572 DC45U9Y Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Gefitinib DCJDC41 Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Clindamycin DCFSHOX Clindamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Aliskiren DCBSY8M Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Diethylcarbamazine DCDQN5K Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Imipramine DCPO895 Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Furazolidone DCJUEJD Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + PMID28460551-Compound-2 DCPM99O PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Vinblastine DCU74BY Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Sivelestat DC6X1JD Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Triapine DCME1CI Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Everolimus DCZ5PV4 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Tranexamic acid DC8AP9T Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Methylergonovine DCSCJ8B Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Metyrosine DCXICS2 Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Chlorzoxazone DCJCZZ7 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Docetaxel DCG8A4X Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Diphenidol DCE1DTE Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Arfolitixorin DCD5ZXX Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Niclosamide DCZZLVL Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Eflornithine DCHOYPK Eflornithine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Oseltamivir DCW008H Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Idarubicin DCKYOEN Idarubicin Glioblastoma? (Cell Line: T98G) [2]
BRL-15572 + Methocarbamol DC8YFXC Methocarbamol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Maprotiline DCMMY8T Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Oxyphenbutazone DC19DEQ Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Brincidofovir DCGV9Z2 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Spironolactone DCJDL5K Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Hydralazine DC9USZD Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Fosfomycin DCARU5J Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Cevimeline DC894UK Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Cerivastatin DCUWQ1V Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Tetracycline DCXDNR7 Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clascoterone + BRL-15572 DC2WXPQ Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clopidogrel + BRL-15572 DC6492O Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + BRL-15572 DCFOOE5 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dactinomycin + BRL-15572 DCAVAJ5 Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diazoxide + BRL-15572 DCGUYJD Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Endoxifen + BRL-15572 DCIQWZD Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + BRL-15572 DCL1DEB Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + BRL-15572 DC1BCWG Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + BRL-15572 DCNXR0T IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Levamisole + BRL-15572 DC9FG5A Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Loperamide + BRL-15572 DCD15US Loperamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + BRL-15572 DCNO8XF Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mefloquine + BRL-15572 DCK6VOQ Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Memantine + BRL-15572 DCIUQZE Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + BRL-15572 DCH1QZG Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + BRL-15572 DCUM79L Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + BRL-15572 DC0VKF8 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pepstatin + BRL-15572 DCAKE20 Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + BRL-15572 DC0N8UC Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + BRL-15572 DC4CFW6 Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ursodeoxycholic acid + BRL-15572 DCX3EP1 Ursodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Zileuton + BRL-15572 DC953Z7 Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 57 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 10).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.