Details of the Drug Combinations

General Information of This Drug (ID: DMMRV29)

Drug Name

Telaprevir DMMRV29

Synonyms

402957-28-2; VX-950; Incivek; Telaprevir (VX-950); Incivo; MP-424; VX 950; Telavic; VX-950(Telaprevir); LY-570310; UNII-655M5O3W0U; VRT-111950; CHEMBL231813; CHEBI:68595; 655M5O3W0U; S-Telaprevir; (1S,3aR,6aS)-2-((S)-2-((S)-2-cyclohexyl-2-(pyrazine-6-carboxamido)acetamido)-3,3-dimethylbutanoyl)-N-((S)-1-(cyclopropylamino)-1,2-dioxohexan-3-yl)-octahydrocyclopenta[c]pyrrole-1-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Hepatitis C virus infection	1E51.1	Approved	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Dolutegravir + Telaprevir	DCDOPDU	Dolutegravir	Infection, Human Immunodeficiency Virus	[2]
Telaprevir + Tacrolimus	DCBQPX7	Tacrolimus	Hepatitis C	[3]
Telaprevir + Cyclosporin A	DCDSQM9	Cyclosporin A	Hepatitis C	[3]
Paroxetine + Telaprevir	DCB8C11	Paroxetine	Hepatitis C Infection	[4]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7871).
2	ClinicalTrials.gov (NCT01563328) A Study to Evaluate the Effect of Boceprevir and Telaprevir on Dolutegravir Pharmacokinetics in Healthy Adult Subjects (ING115697).
3	ClinicalTrials.gov (NCT01038167) A Study to Examine the Effects of Telaprevir on the Pharmacokinetics of Cyclosporine and Tacrolimus in Healthy Adults
4	ClinicalTrials.gov (NCT01841502) Interaction Between Paroxetine and Telaprevir