Details of the Drug Combinations

General Information of This Drug (ID: DMNE1FR)

Drug Name

Resminostat DMNE1FR

Synonyms

Resminostat; 864814-88-0; 4SC-201; RAS2410; Resminostat (RAS2410); UNII-1578EUB98L; (E)-3-(1-((4-((dimethylamino)methyl)phenyl)sulfonyl)-1H-pyrrol-3-yl)-N-hydroxyacrylamide; BYK408740; 1578EUB98L; Resminostat [INN]; 4SC 201; Resminostat 4SC-201; Resminostat (4SC-201); SCHEMBL295541; SCHEMBL295540; GTPL7502; EX-A542; DTXSID50235587; MolPort-027-720-936; AOB87187; BCP02538; 4SC201; ZINC13983495; s2693; AKOS030526945; SB16667; DB12392; CS-1521; API0013984; BC261895

Indication

Disease Entry	ICD 11	Status	REF
Hepatocellular carcinoma	2C12.02	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

7 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
ABT-199 + Resminostat	DCWQUUE	ABT-199	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
BMS-754807 + Resminostat	DC8LVMU	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Carfilzomib + Resminostat	DCZ4H70	Carfilzomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Doxorubicin + Resminostat	DCWB76N	Doxorubicin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Resminostat + Marizomib	DCLEHQH	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
RTB101 + Resminostat	DCJOA8Z	RTB101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Trametinib + Resminostat	DC8Y5HL	Trametinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
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⏷ Show the Full List of 7 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7502).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.