Details of the Drug Combinations

General Information of This Drug (ID: DMOFSLE)

Drug Name
IMD-0354   DMOFSLE
Synonyms
IMD-2560; IMD-2560); I-kappaB kinase beta inhibitor (dermatological, atopic dermatitis/acne), Institute of Medicinal MolecularDesign; I-kappaB kinase beta inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD; IKK-beta inhibitor (dermatological, atopic dermatitis/acne), IMMD; IL-6 release inhibitor (oral, rheumatoid arthritis/osteoporosis), IMMD
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

25 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
BMS-754807 + IMD-0354 DCBJ8IK BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
CUDC-101 + IMD-0354 DC3JJ7K CUDC-101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Dasatinib + IMD-0354 DCRIUPZ Dasatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Dorsomorphin + IMD-0354 DCTV84M Dorsomorphin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Fostamatinib + IMD-0354 DCTDUIQ Fostamatinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
IMD-0354 + Gefitinib DCXKBAU Gefitinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
IMD-0354 + JQ1 DCXA4PR JQ1 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
IMD-0354 + Cantharidin DCY9YSJ Cantharidin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
IMD-0354 + THAPSIGARGIN DCHEFHB THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
IMD-0354 + AS602868 DCTWBVI AS602868 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
IMD-0354 + Tamoxifen DC0XGZR Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
IMD-0354 + Ciclopirox DCU24NC Ciclopirox Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
IMD-0354 + Prazosin DCD4RGR Prazosin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
IMD-0354 + Ruxolitinib DC87B0C Ruxolitinib Hodgkin lymphoma (Cell Line: HDLM-2) [3]
IMD-0354 + Dactinomycin DCLP6WP Dactinomycin Hodgkin lymphoma (Cell Line: L-1236) [3]
IMD-0354 + Ym155 DCPS156 Ym155 Hodgkin lymphoma (Cell Line: L-1236) [3]
IMD-0354 + Fomepizole DC7T3OZ Fomepizole Hodgkin lymphoma (Cell Line: L-1236) [3]
IMD-0354 + GDC-0084 DCGY5R1 GDC-0084 Hodgkin lymphoma (Cell Line: L-1236) [3]
IMD-0354 + AS602868 DCV0KFH AS602868 Hodgkin lymphoma (Cell Line: L-1236) [3]
MLN8237 + IMD-0354 DCERGI0 MLN8237 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Palbociclib + IMD-0354 DCA8BD3 Palbociclib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
RAF265 + IMD-0354 DCYUSXQ RAF265 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
SNDX-275 + IMD-0354 DC1BZJP SNDX-275 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
SNS-032 + IMD-0354 DCVF364 SNS-032 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Vincristine + IMD-0354 DCFBWD1 Vincristine Hodgkin lymphoma (Cell Line: L-1236) [2]
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⏷ Show the Full List of 25 DrugCom(s)

References

1 Activation of histamine H4 receptor inhibits TNFalpha/IMD-0354-induced apoptosis in human salivary NS-SV-AC cells. Apoptosis. 2014 Dec;19(12):1702-11.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.