Details of the Drug Combinations

General Information of This Drug (ID: DMON4IL)

Drug Name

TG100-115 DMON4IL

Synonyms

TG-100115; TG-100-115; TG100115, TG100-115; 3,3'-(2,4-diaminopteridine-6,7-diyl)diphenol; 3-(2,4-diamino-6-(3-hydroxyphenyl)pteridin-7-yl)phenol; 3-[2,4-diamino-7-(3-hydroxyphenyl)pteridin-6-yl]phenol

Indication

Disease Entry	ICD 11	Status	REF
Angioedema	4A00.15	Phase 1/2	[1]
Myocardial infarction	BA41-BA43	Phase 1/2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

9 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
TG100-115 + Sitosterol	DCXOKDB	Sitosterol	Hepatoblastoma (Cell Line: HB3)	[2]
TG100-115 + Ruxolitinib	DCDOZ60	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
TG100-115 + Marizomib	DCZXFJ9	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
TG100-115 + KN-62	DCER5QQ	KN-62	Hepatoblastoma (Cell Line: HB3)	[2]
TG100-115 + Idarubicin	DCLWJQH	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
TG100-115 + Quinine	DCQPNO5	Quinine	DD2 (Cell Line: DD2)	[2]
TG100-115 + Quinine	DCO4AT1	Quinine	Hepatoblastoma (Cell Line: HB3)	[2]
TG100-115 + Piperaquine	DC66ITC	Piperaquine	DD2 (Cell Line: DD2)	[2]
TG100-115 + Pyronaridine	DCGS3LR	Pyronaridine	Hepatoblastoma (Cell Line: HB3)	[2]
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⏷ Show the Full List of 9 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5715).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.