Details of the Drug Combinations

General Information of This Drug (ID: DMONGIR)

Drug Name

Tosyl-l-arginine methyl ester DMONGIR

Synonyms

Tame; 901-47-3; Methyl P-toluenesulfonyl-L-argininate; Ts-Arg-OMe; tosyl-arginine methyl ester; UNII-1H7BKF44U1; p-toluenesulfonyl-L-arginine methyl ester; tosyl-L-arginine methyl ester; CHEMBL44752; methyl (2S)-5-(diaminomethylideneamino)-2-[(4-methylphenyl)sulfonylamino]pentanoate; 1H7BKF44U1; CHEBI:62167; methyl N(2)-(p-tosyl)-L-argininate; p-toluensulfonyl-L-arginine methyl ester; N(alpha)-p-tosyl-L-arginine methyl ester; (S)-methyl 5-guanidino-2-(4-methylphenylsulfonamido)pentanoate; methyl N(2)-(p-toluenenesulfonyl)-L-argininate; methyl N(2)-[(p-tolyl)sulphonyl]-L-argininate; N(2)-(p-tolylsulfonyl)-L-arginine methyl ester; methyl N(2)-[(4-methylphenyl)sulfonyl]-L-argininate; L-Arginine, N2-((4-methylphenyl)sulfonyl)-, methyl ester; TOSYLARGININE METHYL ESTER; TAME/; SCHEMBL324561; p-tosyl-l-arginine methyl ester; Nalpha-tosylarginine methyl ester; BCPP000052; ZINC1639578; ABP000326; BDBM50070707; s2225; AKOS030214485; CCG-264948; CS-0466; alpha-N-p-Tosyl-L-arginine methyl ester; NCGC00346615-01; HY-13255; SW219688-1; X7573; N-alpha-Toluenesulfonyl-L-arginine methyl ester; W-5260; AB01566842_01; p-TOLUENESULFONYL-L-ARGININE METHYL ESTER HCl; Q27131658; (S)-5-Guanidino-2-(toluene-4-sulfonylamino)-pentanoic acid methyl ester

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Preclinical	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

13 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Tosyl-l-arginine methyl ester + Buparlisib	DCZF86F	Buparlisib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + PD-0325901	DCIJZF9	PD-0325901	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + MK-1775	DCH6IVL	MK-1775	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + JQ1	DCNF6GW	JQ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + Crizotinib	DCWTLVZ	Crizotinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + Panobinostat	DCEN9SU	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + Selumetinib	DCPBTVW	Selumetinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + Evacetrapib	DCY0WGU	Evacetrapib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + Erlotinib	DCUU9QF	Erlotinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + Venglustat	DCQYJNO	Venglustat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + BMS-754807	DCVMFRD	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + PF-562271	DC5Y7B8	PF-562271	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Tosyl-l-arginine methyl ester + Dasatinib	DCN9MLQ	Dasatinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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⏷ Show the Full List of 13 DrugCom(s)

References

1	Emerging therapies targeting the ubiquitin proteasome system in cancer. J Clin Invest. 2014 Jan;124(1):6-12.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.