Details of the Drug Combinations

General Information of This Drug (ID: DMOTQ1I)

• Drug Name: Ondansetron (DMOTQ1I)
• Synonyms: DESMETHYLONDANSETRON; Zofran; Zophren; Zudan; Sandoz ondansetron; ZOFRAN IN PLASTIC CONTAINER; Zofran ODT; GR 38032; GR 38032X; GR38032F; Apo-ondansetron; GR-38032F; Novo-ondansetron; Ondansetron (Zofran); PHL-ondansetron; PMS-ondansetron; Ratio-ondansetron; SN-307; Zofran (TN); Zofran ODT (TN); Ondansetron [USAN:INN:BAN]; Ondansetron (JAN/USP/INN); Ondansetron, (+,-)-Isomer; (RS)-1,2,3,9-Tetrahydro-9-methyl-3-(2-methylimidazol-1-ylmethyl)carbazol-4-one; 1,2,3,9-Tetrahydro-9-methyl-3-((2-methyl-1H-imidazol-1-yl)methyl)-4H-carbazol-4-one; 9-Methyl-3-(2-methyl-imidazol-1-ylmethyl)-1,2,3,9-tetrahydro-carbazol-4-one; 9-methyl-3-[(2-methyl-1H-imidazol-1-yl)methyl]-1,2,3,9-tetrahydro-4H-carbazol-4-one; 9-methyl-3-[(2-methylimidazol-1-yl)methyl]-2,3-dihydro-1H-carbazol-4-one

Indication

Chemotherapy-induced nausea; ICD 11: MD90; Status: Approved [1]; Malignant glioma; ICD 11: 2A00.0; Status: Approved [2]; Nausea; ICD 11: MD90; Status: Approved [2]; Vomiting; ICD 11: MD90; Status: Approved [2]; Alcohol dependence; ICD 11: 6C40.2; Status: Phase 2 [1]; Gastroenteritis; ICD 11: N.A.; Status: Investigative [2]

• Therapeutic Class: Antiemetics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ondansetron + Ruxolitinib	DCLA1QF	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]

24 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Aprepitant + Ondansetron	DC3WL60	Aprepitant	Nausea	[4]
Aprepitant + Ondansetron	DC8N8TH	Aprepitant	Hematologic Diseases	[5]
Bremelanotide + Ondansetron	DCYVK4L	Bremelanotide	Nausea	[6]
Cyproheptadine + Ondansetron	DCGS5EY	Cyproheptadine	Nausea	[7]
Dexamethasone + Ondansetron	DCPF16C	Dexamethasone	Post-Operative Nausea and Vomiting	[8]
Dexamethasone + Ondansetron	DCDU4XS	Dexamethasone	Nausea	[9]
Dexamethasone + Ondansetron	DCGNDPC	Dexamethasone	Chemotherapy-Induced Nausea and Vomiting	[10]
Diazepam + Ondansetron	DC1PHPP	Diazepam	Cataract	[11]
Diphenhydramine + Ondansetron	DCB7GD0	Diphenhydramine	Itching	[12]
Methotrexate + Ondansetron	DC0GFSX	Methotrexate	Juvenile Idiopathic Arthritis	[13]
Ondansetron + Acetylcysteine	DC64DJO	Acetylcysteine	Overdose	[14]
Ondansetron + Olanzapine	DCK3AT2	Olanzapine	Alcohol Dependence	[15]
Dexamethasone + Ondansetron	DCRGPGW	Dexamethasone	Emesis	[16]
Dexamethasone + Ondansetron	DCS3KOO	Dexamethasone	CINV	[17]
Rolapitant + Ondansetron	DC0QWMO	Rolapitant	Chemo-radiation Induced Nausea and Vomiting	[18]
2-Propanol, Isopropanol + Ondansetron	DCCTFOF	2-Propanol, Isopropanol	Nausea	[19]
Dexamethasone + Ondansetron	DCY5VJE	Dexamethasone	Postoperative Nausea and Vomiting (PONV)	[20]
Ketamine + Ondansetron	DCMUQ47	Ketamine	Trigeminal Neuralgia	[21]
Metoclopramide + Ondansetron	DC91J70	Metoclopramide	Postoperative Pain	[22]
Metoclopramide + Ondansetron	DC531GA	Metoclopramide	Nausea	[23]
Ondansetron + Sufentanil	DC9HM2A	Sufentanil	Trigeminal Neuralgia	[21]
Ondansetron + Lactulose	DCAUJA1	Lactulose	Motility Disorder of Intestine	[24]
Palonosetron + Ondansetron	DCEKEYS	Palonosetron	PONV	[25]
Pregabalin + Ondansetron	DCIR09J	Pregabalin	Anxiety	[26]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2290).
• [2] Ondansetron FDA Label
• [3] Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
• [4] ClinicalTrials.gov (NCT01450826) Emend and Ondansetron Compared to Ondansetron Alone to Prevent CINV in Glioma Patients Receiving Temozolomide
• [5] ClinicalTrials.gov (NCT00954941) Ondansetron Versus Aprepitant Plus Ondansetron for Emesis
• [6] ClinicalTrials.gov (NCT03973047) Study to Evaluate Rate of Nausea in Healthy Premenopausal Female Subjects Treated With Single Dose of Bremelanotide Alone or With Zofran
• [7] ClinicalTrials.gov (NCT03593811) Noninvasive Markers of Functional Nausea in Children
• [8] ClinicalTrials.gov (NCT02473042) Intraoperative Acupoint Stimulation to Prevent Post-Operative Nausea and Vomiting (PONV)
• [9] ClinicalTrials.gov (NCT00314743) Efficacy & Safety of the Oral Neurokinin-1 Antagonist, Aprepitant, in Combo With Ondansetron & Dexamethasone in Patients Undergoing Auto Peripheral Blood Stem Cell Transplantation
• [10] ClinicalTrials.gov (NCT00818259) A Study of MK-0869 (Aprepitant) and MK-0517 (Fosaprepitant) in Pediatric Participants Receiving Chemotherapy (MK-0869-134)
• [11] ClinicalTrials.gov (NCT03653520) Conscious Sedation Efficacy of the MKO Melt (Midazolam, Ketamine, Ondansetron)
• [12] ClinicalTrials.gov (NCT00137202) Post Burn Pruritus Study in Patients Undergoing Wound Healing
• [13] ClinicalTrials.gov (NCT04169828) The Ondansetron Premedication Trial in Juvenile Idiopathic Arthritis
• [14] ClinicalTrials.gov (NCT01050270) Scottish and Newcastle Anti-emetic Pre-treatment for Paracetamol Poisoning Study (SNAP)
• [15] ClinicalTrials.gov (NCT00678457) Ondansetron With Olanzapine for the Treatment of Alcohol Dependence: A Preliminary Clinical Trial
• [16] ClinicalTrials.gov (NCT03478605) Trial to Evaluate Efficacy of Olanzapine With Short-acting 5HT3 Inhibitors in Chemotherapy-induced Nausea & Vomiting (CINV) Prophylaxis
• [17] ClinicalTrials.gov (NCT01857232) Dose-finding Study of APD403 to Prevent Nausea and Vomiting After Chemotherapy. U.S. National Institutes of Health.
• [18] ClinicalTrials.gov (NCT02991456) Rolapitant as an Antiemetic in Malignant Glioma Patients Receiving Radiotherapy and Temozolomide
• [19] ClinicalTrials.gov (NCT02760069) Isopropyl Alcohol vs Ondansetron for Nausea in the Emergency Department
• [20] ClinicalTrials.gov (NCT01474915) Aprepitant Versus Ondansetron in Preoperative Triple-therapy Treatment of Nausea and Vomiting
• [21] ClinicalTrials.gov (NCT03152955) Postoperative Analgesia in Patients With Microvascular Decompression
• [22] ClinicalTrials.gov (NCT01837394) Ultrasound-guided Blocks for Ambulatory Knee Arthroscopy
• [23] ClinicalTrials.gov (NCT02959840) Acupuncture Point P6 Stimulation for Reduction of Nausea and Vomiting During Cesarean
• [24] ClinicalTrials.gov (NCT03833999) Mode of Action of Ondansetron, a 5-HT Receptor 3 Antagonist, in Lactulose Induced Diarrhoea
• [25] ClinicalTrials.gov (NCT02468323) Prophylactic Antiemetic Efficacy of Palonosetron Versus Ondansetron for Cesarean Sections Under Regional Anesthesia
• [26] ClinicalTrials.gov (NCT05221151) Melatonin vs Pregabalin for Anxiolysis and Sedation