Details of the Drug Combinations

General Information of This Drug (ID: DMPF9ZM)

Drug Name

Obatoclax DMPF9ZM

Synonyms

CHEMBL408194; UNII-QN4128B52A; QN4128B52A; SCHEMBL631676; SCHEMBL16340850; BDBM50376902; ZINC136873052; DB12191; NCGC00387855-01; BRD-K15600710-066-01-7

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

9 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
ABT-263 + Obatoclax	DC5JNSQ	ABT-263	Glioblastoma (Cell Line: JHH-136)	[2]
AZD8055 + Obatoclax	DC2RQ39	AZD8055	Glioblastoma (Cell Line: JHH-136)	[3]
Bardoxolone methyl + Obatoclax	DCZZEUA	Bardoxolone methyl	Glioblastoma (Cell Line: JHH-136)	[3]
CA4P + Obatoclax	DCW09TM	CA4P	Glioblastoma (Cell Line: JHH-136)	[3]
Cladribine + Obatoclax	DC6HBJI	Cladribine	Glioblastoma (Cell Line: JHH-136)	[3]
GDC0941 + Obatoclax	DCIAJWJ	GDC0941	Glioblastoma (Cell Line: JHH-136)	[3]
Obatoclax + Trametinib	DCZXY5O	Trametinib	Glioblastoma (Cell Line: JHH-136)	[2]
Obatoclax + Panobinostat	DCE6TNX	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Topetecan + Obatoclax	DCCWSTG	Topetecan	Glioblastoma (Cell Line: JHH-136)	[3]
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⏷ Show the Full List of 9 DrugCom(s)

References

1	Phase II study of obatoclax mesylate (GX15-070), a small-molecule BCL-2 family antagonist, for patients with myelofibrosis. Clin Lymphoma Myeloma Leuk. 2010 Aug;10(4):285-9.
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.