Details of the Drug Combinations

General Information of This Drug (ID: DMQLODU)

Drug Name

Citarinostat DMQLODU

Synonyms

ACY-241; 1316215-12-9; HDAC-IN-2; 2-((2-Chlorophenyl)(phenyl)amino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide; UNII-441P620G3P; 441P620G3P; Citarinostat [USAN]; Citarinostat (USAN); 2-(N-(2-chlorophenyl)anilino)-N-[7-(hydroxyamino)-7-oxoheptyl]pyrimidine-5-carboxamide; 2-((2-Chlorophenyl)phenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)-5-pyrimidinecarboxamide; 2-[(2-Chlorophenyl)phenylamino]-N-[7-(hydroxyamino)-7-oxoheptyl]-5-pyrimidinecarboxamide; Citarinostat (ACY-241); SCHEMBL2225863; GTPL942

Indication

Disease Entry	ICD 11	Status	REF
Multiple myeloma	2A83	Phase 1	[1]
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Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

13 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
BMS-754807 + Citarinostat	DCCNT98	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Citarinostat + Prochlorperazine	DCL4PHV	Prochlorperazine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Citarinostat + RTB101	DC0Y9SM	RTB101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Citarinostat + Gemcitabine	DC4ABNM	Gemcitabine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Citarinostat + Marizomib	DC3HMV3	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Citarinostat + Mebendazole	DCNWZRP	Mebendazole	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Citarinostat + CF102	DCI50WF	CF102	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Citarinostat + BMS-754807	DCNH812	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Citarinostat + Doxorubicin	DC6KYXT	Doxorubicin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Doxorubicin + Citarinostat	DCP297X	Doxorubicin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Mitomycin + Citarinostat	DCGGFSM	Mitomycin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
RTB101 + Citarinostat	DCTB8RL	RTB101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
THZ1 + Citarinostat	DC1A7Z3	THZ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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⏷ Show the Full List of 13 DrugCom(s)

References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.