Details of the Drug Combinations

General Information of This Drug (ID: DMQTJSX)

Drug Name

Fluvoxamine DMQTJSX

Synonyms

Dumyrox; Fluvoxamina; Fluvoxaminum; Fluvoxamina [INN-Spanish]; Fluvoxamine (INN); Fluvoxamine [INN:BAN]; Fluvoxamine-CR; Fluvoxaminum [INN-Latin]; Luvox (TN); (1E)-5-methoxy-1-[4-(trifluoromethyl)phenyl]pentan-1-one O-(2-aminoethyl)oxime; 2-[(E)-[5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene]amino]oxyethanamine; 2-[({5-methoxy-1-[4-(trifluoromethyl)phenyl]pentylidene}amino)oxy]ethanamine

Indication

Disease Entry	ICD 11	Status	REF
Depression	6A70-6A7Z	Approved	[1]
Obsessive compulsive disorder	6B20	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[3]
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Therapeutic Class

Antidepressants

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Fluvoxamine + Ketoconazole	DCW83WS	Ketoconazole	Pharmacology, Clinical	[4]
Fluvoxamine + Digoxin	DC0I4GT	Digoxin	Depression	[5]
Metformin + Fluvoxamine	DCFG5WZ	Metformin	Covid19	[6]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7189).
2	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 075893.
3	ClinicalTrials.gov (NCT04342663) A Double-blind, Placebo-controlled Clinical Trial of Fluvoxamine for Symptomatic Individuals With COVID-19 Infection. U.S. National Institutes of Health.
4	ClinicalTrials.gov (NCT01707407) A Phase 1 Open-Label Study to Evaluate the Effect of CYP450 and P-gp Inhibition and Induction on the Pharmacokinetics of Pomalidomide (CC-4047) in Healthy Male Subjects
5	ClinicalTrials.gov (NCT01704638) Kinetics of Fluvoxamine and Digoxin in Subjects With Different MDR1 Genotypes
6	ClinicalTrials.gov (NCT04510194) COVID-OUT: Early Outpatient Treatment for SARS-CoV-2 Infection (COVID-19)