Details of the Drug Combinations

General Information of This Drug (ID: DMQWS6U)

Drug Name

KU-0060648 DMQWS6U

Synonyms

KU 0060648

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Doxorubicin + KU-0060648	DC6HOAE	Doxorubicin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
Flavopiridol + KU-0060648	DCZ21M9	Flavopiridol	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
KU-0060648 + Mitomycin	DC0PO9X	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
KU-0060648 + PF-562271	DC2X43F	PF-562271	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
KU-0060648 + Ibrutinib	DC61O2N	Ibrutinib	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
------------------------------------------------------------------------------------

References

1	Chemosensitization of cancer cells by KU-0060648, a dual inhibitor of DNA-PK and PI-3K. Mol Cancer Ther. 2012 Aug;11(8):1789-98.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.