Details of the Drug Combinations

General Information of This Drug (ID: DMR27C8)

• Drug Name: Artesunate (DMR27C8)
• Synonyms: Arinate; Arsumax; Artesunato; Artesunatum; Artsuna; Dihydroqinghaosusuccinate; Nuartez; Plasmotrim; Plasmotrin; Qinghaozhi; Artesunic acid; Dihydroqinghasu hemsuccinate; Quinghaosu reduced succinate ester; Succinyl dihydroartemisinin; SM 804; WR 256283; Arsumax (TN); Artesunate (USAN); Artesunate (superseded RN); Artesunato [INN-Spanish]; Artesunatum [INN-Latin]; WR-256283; Dihydroartemisinine-12-alpha-succinate; Butanedioic acid, mono(decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester; Butanedioic acid, mono((3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-yl) ester; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Decahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano(4,3-j)-1,2-benzodioxepin-10-ol, hydrogen succinate; 4-Oxo-4-(((3R,5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxypyrano(4,3-j)-1,2-benzodioxepin-10-yl hydrogen butanedioate; 4-oxo-4-{[(3r,5as,6r,8as,9r,10r,12r,12ar)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid; 4-oxo-4-{[(5aS,6R,8aS,9R,10S,12R,12aR)-3,6,9-trimethyldecahydro-3,12-epoxy[1,2]dioxepino[4,3-i]isochromen-10-yl]oxy}butanoic acid

Indication

Infection of P. falciparum; ICD 11: 1F40; Status: Approved [1]; Malaria; ICD 11: 1F40-1F45; Status: Approved [2]; Plasmodium falciparum malaria; ICD 11: 1F40; Status: Approved [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

8 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Amodiaquine + Artesunate	DCJDKVE	Amodiaquine	HIV Infections	[3]
Artesunate + Chloroquine	DCNDOA2	Chloroquine	Uncomplicated Falciparum Malaria	[4]
Artesunate + Mefloquine	DCPG5FB	Mefloquine	Plasmodium Falciparum Malaria	[5]
Artesunate + Chloroquine	DCPMMUQ	Chloroquine	Plasmodium Falciparum Infection	[6]
GS-9620 + Artesunate	DCUFG0T	GS-9620	HIV-1 Infection	[7]
Artesunate + Romidepsin	DCAB9X9	Romidepsin	Hiv	[8]
Curcumin + Artesunate	DCZ8E1J	Curcumin	Crohn's Disease	[9]
Artesunate + Quinine	DCQ24P0	Quinine	Malaria	[10]

References

• [1] Artesunate FDA Label
• [2] The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
• [3] ClinicalTrials.gov (NCT00356824) Relationship Between HIV and Malaria in Ugandan Children
• [4] ClinicalTrials.gov (NCT00959517) Trial of Artesunate Combination Therapy in Pakistan
• [5] ClinicalTrials.gov (NCT01659281) Efficacy of Artesunate-Mefloquine Combination Therapy in Trat Province, Thailand
• [6] ClinicalTrials.gov (NCT00379821) Chloroquine Alone or in Combination for Malaria in Children in Malawi
• [7] ClinicalTrials.gov (NCT03060447) Study to Evaluate the Safety and Efficacy of Vesatolimod in Antiretroviral Treated Human Immunodeficiency Virus (HIV-1) Infected Controllers
• [8] ClinicalTrials.gov (NCT03041012) Early Administration of Romidepsin and 3BNC117 in Treatment-nave HIV Patients Starting ART
• [9] ClinicalTrials.gov (NCT04713631) Safety and Efficacy of Artesunate & Curcumin in Crohn's Disease
• [10] ClinicalTrials.gov (NCT01805232) Intravenous Artesunate and Malaria