General Information of This Drug (ID: DMR87LC)

Drug Name
Ethambutol   DMR87LC
Synonyms
Aethambutolum; Diambutol; EMB; Etambutol; Etambutolo; Ethambutolum; Etibi; Miambutol; Myambutol; Purderal; Servambutol; Tibutol; Etambutolo [DCIT]; CL 40881 (dihydrochloride); D-Ethambutol; Etambutol [INN-Spanish]; Ethambutol & EEP; Ethambutol & Propolis; Ethambutol (INN); Ethambutol [INN:BAN]; Ethambutol, meso form; Ethambutol, racemic mixture; Ethambutolum [INN-Latin]; Myambutol (TN); Myambutol (dihydrochloride); Servambutol (TN); Ethambutol, (-)-isomer; D,N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine; D-N,N'-Bis(1-hydroxymethylpropyl)ethylenediamine; D-2,2'-(Ethylenediimino)bis(1-butanol); D-2,2'-(Ethylenediimino)di-1-butanol; (+)-(S,S)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (+)-2,2'-(Ethylenediimino)di-1-butanol; (+)-N,N'-Bis(1-(hydroxymethyl)propyl)ethylenediamine; (+)-S,S-Ethambutol; (+)-ethambutol; (-)-(R,R)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (2'S)-2,2'-[Ethane-1,2-diyldi(imino)]dibutan-1-ol; (2R)-2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol; (2R)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol; (2S)-2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol; (2S)-2-[2-[[(2R)-1-hydroxybutan-2-yl]amino]ethylamino]butan-1-ol; (2S,2'S)-2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol; (2S,7S)-2,7-diethyl-3,6-diazaoctane-1,8-diol; (R)-2,2'-(1,2-Ethanediyldiimino)bis-1-butanol; (S,R)-2,2'-(1,2-Ethylenediimino)-di-1-butanol; (S,S)-ethambutol; 2,2'-(1,2-Ethylenediimino)-di-1-butanol; 2,2'-(ethane-1,2-diyldiimino)dibutan-1-ol; 2-[2-(1-hydroxybutan-2-ylamino)ethylamino]butan-1-ol
Indication
Disease Entry ICD 11 Status REF
Pulmonary tuberculosis 1B10.Z Approved [1]
Therapeutic Class
Antitubercular Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

54 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + Ethambutol DCEAC2N Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Allopurinol + Ethambutol DCFX8FC Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Amodiaquine + Ethambutol DCC9TCE Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Ethambutol DC4J6U6 Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Ethambutol DCJL43P Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bepridil + Ethambutol DCFZARX Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Ethambutol DC0UWM6 Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Ethambutol DCPKW77 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dantrolene + Ethambutol DCU6HM5 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diethylcarbamazine + Ethambutol DCY617Y Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Endoxifen + Ethambutol DC46FFO Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + Ethambutol DC9QORN Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Primidone DCWDV5Y Primidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Gefitinib DCSBRCI Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + PMID28460551-Compound-2 DCITW2N PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Methotrexate DCAOU91 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Vinblastine DCA5FMQ Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Testosterone cypionate DCZTOXF Testosterone cypionate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Chlorzoxazone DCEKV8B Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Pentamidine DCVZOR5 Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + BIO-300 DCSQHCL BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Niclosamide DCKAGAR Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Etonogestrel DC19OHD Etonogestrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Idarubicin DC76903 Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Methocarbamol DCBRR0U Methocarbamol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Probenecid DCFD6WL Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Atenolol DCQRBGB Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Methylene blue DCTMT54 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Topotecan DC2QPYJ Topotecan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Olanzapine DC7RCI7 Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Brincidofovir DCLZSTL Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Sorafenib DCT0N95 Sorafenib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Mefloquine DCK1HUQ Mefloquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Pizotyline DCOMXOH Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Doxorubicin DCX72GR Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Estramustine DCDA0K5 Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Cerivastatin DCVC88K Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Metaxalone DCYGDBU Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ethambutol + Albendazole DC5O24V Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Everolimus + Ethambutol DCWVGZ1 Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hyodeoxycholic acid + Ethambutol DC47IKU Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Ethambutol DCK4C6E Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Ethambutol DCN1ZNK IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Ethambutol DC80OY6 Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Miglustat + Ethambutol DCFTL8Z Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Ethambutol DC0AJ5T Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + Ethambutol DCZ0ZBL Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Spironolactone + Ethambutol DCM3SQW Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + Ethambutol DC724PW Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + Ethambutol DCPRLKQ Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triapine + Ethambutol DC21BYT Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Triflupromazine + Ethambutol DCU0I0Y Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Valproic Acid + Ethambutol DCJBYYO Valproic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vorinostat + Ethambutol DCOV7LO Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 54 DrugCom(s)
5 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Rifampicin + Ethambutol DCAS3RT Rifampicin Cystic Fibrosis [4]
Ethambutol + Azithromycin DC3CX2X Azithromycin Mycobacterium Avium Complex [5]
Rifampicin + Ethambutol DCZE88D Rifampicin Sarcoidosis; Antimycobacterial Therapy [6]
Rifampicin + Ethambutol DCVPBCS Rifampicin Lung Infection [7]
Rifampicin + Ethambutol DCTTE4F Rifampicin Nontuberculous Mycobacterial Lung Disease [8]
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References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT02372383) Improving Treatment of Nontuberculous Mycobacterial Infection in Cystic Fibrosis
5 ClinicalTrials.gov (NCT03672630) Comparison of Two- Versus Three-antibiotic Therapy for Pulmonary Mycobacterium Avium Complex Disease
6 ClinicalTrials.gov (NCT02024555) Phase II Investigation of Antimycobacterial Therapy on Progressive, Pulmonary Sarcoidosis
7 ClinicalTrials.gov (NCT03236987) CLArithromycin Versus AZIthromycin in the Treatment of Mycobacterium Avium Complex (MAC) Lung Infections
8 ClinicalTrials.gov (NCT04921943) Hypertonic Saline for MAC