Details of the Drug Combinations

General Information of This Drug (ID: DMR8ONJ)

Drug Name

Leflunomide DMR8ONJ

Synonyms

Arava; Leflunomid; Leflunomida; Leflunomidum; Lefunamide; Aventis Behring Brand of Leflunomide; Aventis Brand of Leflunomide; Aventis Pharma Brand of Leflunomide; Hoechst Brand of Leflunomide; HWA 486; L 5025; SU 101; SU101; Arava (TN); Arava, Leflunomide; HWA-486; Leflunomida [INN-Spanish]; Leflunomide [USAN:INN]; Leflunomidum [INN-Latin]; Lefunomide [Inn-Spanish]; RS-34821; SU 101 (pharmaceutical); SU-101; AP-501/42475599; Leflunomide (JAN/USAN/INN); N-(4-trifluoromethyphenyl)-5-methylisoxazole-4-carboxamide; N-(4'-Trifluoromethylphenyl)-5-methylisoxazole-4-carboxamide; Alpha,alpha,alpha-Trifluoro-5-methyl-4-isoxazolecarboxy-p-toluidide; 4-Isoxazolecarboxamide, 5-methyl-N-(4-(trifluoromethyl)phenyl; 4-isoxazolecarboxamide,5-methyl-N-(4-(trifluoromethyl)phenyl); 5-Methyl-N-(4-(trifluoromethyl)phenyl)-4-isoxazolecarboxamide; 5-Methylisoxazole-4-(4-trifluoromethyl)carboxanilide; 5-Methylisoxazole-4-(4-trifluoromethylcarboxanilide); 5-Methylisoxazole-4-carboxylic acid (4-trifluoromethyl)anilide; 5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide; 5-methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide; 5-methyl-N-[4-(trifluoromethyl)phenyl]isoxazole-4-carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Arthritis	FA20	Approved	[1]
Lupus nephritis	4A40.0Y	Approved	[2]
Multiple sclerosis	8A40	Approved	[3]
Psoriatic arthritis	FA21	Approved	[2]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1	[4]
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Therapeutic Class

Antiinflammatory Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

169 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
10-hydroxycamptothecin + Leflunomide	DCR279X	10-hydroxycamptothecin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Acamprosate + Leflunomide	DCFVZE8	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Acarbose + Leflunomide	DCTFS41	Acarbose	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Acetazolamide + Leflunomide	DCNXV2S	Acetazolamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aciclovir + Leflunomide	DCDMBGZ	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Acitretin + Leflunomide	DCQSNT8	Acitretin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Albendazole + Leflunomide	DC9Z1OZ	Albendazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Amiloride + Leflunomide	DCOS1HC	Amiloride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Aminosalicylic acid + Leflunomide	DCHQ34W	Aminosalicylic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Anamorelin + Leflunomide	DC254P8	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Atovaquone + Leflunomide	DCG6T7K	Atovaquone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Azatadine + Leflunomide	DCJXE63	Azatadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Bepridil + Leflunomide	DCSGNNL	Bepridil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Bortezomib + Leflunomide	DCHBU6I	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Bosentan + Leflunomide	DCHSAOD	Bosentan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Brincidofovir + Leflunomide	DCNSOUM	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Bumetanide + Leflunomide	DCMQKSG	Bumetanide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Busulfan + Leflunomide	DCD4PSW	Busulfan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Carglumic acid + Leflunomide	DCZO0G2	Carglumic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Chlormezanone + Leflunomide	DCLZD6O	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Chloroquine + Leflunomide	DCBRXN0	Chloroquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Cilastatin + Leflunomide	DC3HI7D	Cilastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Cilostazol + Leflunomide	DCKO1JO	Cilostazol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Cisatracurium + Leflunomide	DCG2P5C	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Citalopram + Leflunomide	DC6W8RZ	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Clindamycin + Leflunomide	DC9ZW9N	Clindamycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Clopidogrel + Leflunomide	DCR6NYD	Clopidogrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Cycloguanil + Leflunomide	DC4DI4G	Cycloguanil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Daidzin + Leflunomide	DCO4A5D	Daidzin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Desoxycorticosterone pivalate + Leflunomide	DCNYCFZ	Desoxycorticosterone pivalate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Dexmedetomidine + Leflunomide	DCUBSFB	Dexmedetomidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Dextromethorphan + Leflunomide	DCABJED	Dextromethorphan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Dichlorphenamide + Leflunomide	DCC7KNS	Dichlorphenamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Diethylcarbamazine + Leflunomide	DCGLNYI	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Dihydroergotamine + Leflunomide	DCR1A5O	Dihydroergotamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Diphenidol + Leflunomide	DCGXXXB	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Doxapram + Leflunomide	DCHAZD7	Doxapram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Doxorubicin + Leflunomide	DCHNG8A	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Dronedarone + Leflunomide	DCAGXNR	Dronedarone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Emetine + Leflunomide	DCNKOBT	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Endoxifen + Leflunomide	DC3I0LP	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Epinephrine + Leflunomide	DCWNTUW	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Eptifibatide + Leflunomide	DCVSUPZ	Eptifibatide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ethinyl estradiol + Leflunomide	DCSWO2R	Ethinyl estradiol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
ETHISTERONE + Leflunomide	DCBSZ9A	ETHISTERONE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Etomidate + Leflunomide	DCPH133	Etomidate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Fibrates + Leflunomide	DCF7NER	Fibrates	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Flavonoid derivative 1 + Leflunomide	DCTLCEH	Flavonoid derivative 1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Furazolidone + Leflunomide	DC60ZKH	Furazolidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ginsenoside Rb1 + Leflunomide	DCKX364	Ginsenoside Rb1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
GYKI-52466 + Leflunomide	DC6R9VW	GYKI-52466	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Hydralazine + Leflunomide	DCXQEYT	Hydralazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Imipramine + Leflunomide	DCZ269G	Imipramine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
JZL195 + Leflunomide	DCVK9CO	JZL195	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
K-134 + Leflunomide	DCTWGBN	K-134	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
L-165041 + Leflunomide	DCB5S97	L-165041	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Lacosamide + Leflunomide	DC1Q13S	Lacosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Aprepitant	DCCEV8J	Aprepitant	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Baclofen	DCMIUH1	Baclofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Primidone	DC0WZRR	Primidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Aliskiren	DC7IB5C	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Citalopram	DCMTI29	Citalopram	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Dactinomycin	DC65XVK	Dactinomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Terazosin	DCKQQ7R	Terazosin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Trioxsalen	DC8EX02	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Mephenytoin	DC95S7E	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Ezetimibe	DCE71I1	Ezetimibe	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Triapine	DCHFBYA	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Pamidronate	DCDC2H6	Pamidronate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Isosorbide dinitrate	DCJ9XUU	Isosorbide dinitrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Buspirone	DCSYKFZ	Buspirone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Guanfacine	DC5VGDR	Guanfacine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Itraconazole	DCL5AXH	Itraconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Ursodeoxycholic acid	DC72NC8	Ursodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Pazopanib	DC91PHM	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Sitagliptin	DCXIE6S	Sitagliptin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Nizatidine	DC936QZ	Nizatidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Diphenidol	DCPU0SF	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Pentamidine	DCB7E28	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Eflornithine	DC6X3W1	Eflornithine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Etonogestrel	DCYQ6Z2	Etonogestrel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + GINKGOLIDE A	DCCKZ2N	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Allopurinol	DC3YZJ6	Allopurinol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Benserazide	DCUZRGQ	Benserazide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Pargyline	DCOMPFO	Pargyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Idarubicin	DCHEY5D	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Probenecid	DCMGGGI	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Abacavir	DC19LW0	Abacavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Darunavir	DCDW9JN	Darunavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Atenolol	DCLW76J	Atenolol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Pramipexole	DCVWVM2	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Acamprosate	DC2QAK3	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Moricizine	DC90QJR	Moricizine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Topotecan	DC0VI14	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Enalaprilat	DC0L4PX	Enalaprilat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Maprotiline	DCQ8W38	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Chlorambucil	DC6Y73C	Chlorambucil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Amantadine	DC087IQ	Amantadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Valproic Acid	DCW3E8J	Valproic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Sorafenib	DCVRH44	Sorafenib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Asenapine	DC4Z4DS	Asenapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Naltrexone	DCXA9UZ	Naltrexone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Pomalidomide	DCJZNT8	Pomalidomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Maraviroc	DCTQZYJ	Maraviroc	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Mycophenolic acid	DCZJI8N	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Oxandrolone	DCMQ599	Oxandrolone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Nitisinone	DCFSBTI	Nitisinone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Testolactone	DCMSD3V	Testolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Olmesartan medoxomil	DCXXB83	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Auranofin	DCGQKKA	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Rufinamide	DCSFMUJ	Rufinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + FORMESTANE	DC22QW7	FORMESTANE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Cevimeline	DCE3BWV	Cevimeline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Metaxalone	DCQBG0E	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + GSK2194069	DC9BW3C	GSK2194069	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Leflunomide + Tacrolimus	DCOM1T2	Tacrolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
LIAROZOLE + Leflunomide	DCGKL3Y	LIAROZOLE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Lithium Citrate + Leflunomide	DCHR3GI	Lithium Citrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Lumefantrine + Leflunomide	DCM7AO5	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
LY03004 + Leflunomide	DCWC44B	LY03004	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Mebutamate + Leflunomide	DC42LEN	Mebutamate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Mecamylamine + Leflunomide	DC413CL	Mecamylamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Mesalazine + Leflunomide	DC4I2WZ	Mesalazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Metaxalone + Leflunomide	DCFXZFT	Metaxalone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Metformin + Leflunomide	DCEFXU3	Metformin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Methocarbamol + Leflunomide	DCTO8JR	Methocarbamol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Metyrosine + Leflunomide	DCUNONX	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Miconazole + Leflunomide	DC86ALB	Miconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Miglustat + Leflunomide	DC61CVB	Miglustat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Mycophenolic acid + Leflunomide	DCQUJUO	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Nabilone + Leflunomide	DCKRDKH	Nabilone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Niclosamide + Leflunomide	DC53SLP	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Norcisapride + Leflunomide	DC19D2C	Norcisapride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Olmesartan medoxomil + Leflunomide	DC3ZQW1	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Oxyphenbutazone + Leflunomide	DCZCXDE	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pentostatin + Leflunomide	DCAJQPC	Pentostatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pepstatin + Leflunomide	DCN6AYN	Pepstatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
PF-02545920 + Leflunomide	DCWAI3G	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
PHA-739358 + Leflunomide	DC1Z3XH	PHA-739358	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Phensuximide + Leflunomide	DCHX625	Phensuximide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pinacidil + Leflunomide	DCQ8UVE	Pinacidil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pizotyline + Leflunomide	DCIBB8Z	Pizotyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Procarbazine + Leflunomide	DCYLPQA	Procarbazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Pyrazinamide + Leflunomide	DCRUWRN	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Raltegravir + Leflunomide	DCVZM4I	Raltegravir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Repaglinide + Leflunomide	DCX4XGF	Repaglinide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Ribavirin-TP + Leflunomide	DCTBKJR	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Rifampin + Leflunomide	DCDE0GK	Rifampin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
SCH 727965 + Leflunomide	DCDAXOI	SCH 727965	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Sertraline + Leflunomide	DCD8EMV	Sertraline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Sulfinpyrazone + Leflunomide	DCXZOXZ	Sulfinpyrazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Sumatriptan + Leflunomide	DCUVF4F	Sumatriptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tacrine + Leflunomide	DCNARUQ	Tacrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tamoxifen + Leflunomide	DCP8BVG	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Terameprocol + Leflunomide	DCTH50F	Terameprocol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Testosterone + Leflunomide	DCYVR1S	Testosterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Testosterone cypionate + Leflunomide	DCQCZBO	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tetracycline + Leflunomide	DCUHIKQ	Tetracycline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Theophylline + Leflunomide	DCOUH2W	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tindamax + Leflunomide	DC32QBP	Tindamax	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Tranexamic acid + Leflunomide	DCO6E5A	Tranexamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Trifluoperazine + Leflunomide	DCLFR9R	Trifluoperazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Trihexyphenidyl + Leflunomide	DCIJIZV	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Triiodothyronine + Leflunomide	DC6HNSP	Triiodothyronine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Trimethobenzamide + Leflunomide	DC9EQZF	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
VR-776 + Leflunomide	DCHA9A2	VR-776	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
WAY-100635 + Leflunomide	DC168JB	WAY-100635	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Zaleplon + Leflunomide	DC7N7C2	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
Zileuton + Leflunomide	DCWIQE9	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[5]
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⏷ Show the Full List of 169 DrugCom(s)

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Vemurafenib + Leflunomide	DCHDSD2	Vemurafenib	Melanoma	[6]
Cholestyramine + Leflunomide	DCGAOP1	Cholestyramine	Smoldering Plasma Cell Myeloma	[7]
Methotrexate + Leflunomide	DCAC3BT	Methotrexate	Rheumatoid Arthritis	[8]
Prednisolone + Leflunomide	DCLUM2T	Prednisolone	Immunoglobulin G4 Related Sclerosing Disease	[9]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6825).
2	Leflunomide FDA Label
3	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 077090.
4	ClinicalTrials.gov (NCT04361214) Leflunomide in Mild COVID-19 Patients. U.S. National Institutes of Health.
5	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
6	ClinicalTrials.gov (NCT01611675) Leflunomide+Vemurafenib in V600 Mutant Met. Melanoma
7	ClinicalTrials.gov (NCT05014646) Leflunomide for the Treatment of High-Risk Smoldering Multiple Myeloma in African-American and European-American Patients
8	ClinicalTrials.gov (NCT02275299) Study of Iguratimod Plus Methotrexate Compared to Leflunomid Plus Methotrexate in Patients With Rheumatoid Arthritis
9	ClinicalTrials.gov (NCT02703194) Leflunomide for Maintenance of Remission in IgG4 Related Disease