Details of the Drug Combinations

General Information of This Drug (ID: DMRADYL)

Drug Name
Pinacidil   DMRADYL
Synonyms
Pinacidilum; P 1134; S 1230; P-154; Pinacidil (anhydrous); Pinacidilum [INN-Latin]; S-1230; N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)guanidine; Guanidine, 2-cyano-3-(4-pyridyl)-1-(1,2,2-trimethylpropyl)-, monohydrate; Guanidine, N-cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-, monohydrate; (+-)-Pinacidil; (+/-)-N-Cyano-N'-4-pyridinyl-N"-(1,2,2-trimethylpropyl)guanidine; (R,S)-Pinacidil; (inverted question mark)-N-Cyano-N'-4-pyridinyl-N''-(1,2,2-trimethylpropyl)-guanidine; 1-cyano-2-(3,3-dimethylbutan-2-yl)-3-pyridin-4-ylguanidine; 2-Cyano-3-(4-pyridinyl)-1-(1,2,2-trimethylpropyl)guanidine; 2-Cyano-3-(4-pyridyl)-1-(1,2,2-trimethylpropyl)guanidine monohydrate
Indication
Disease Entry ICD 11 Status REF
High blood pressure BA00 Approved [1]
Therapeutic Class
Antihypertensive Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

75 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Dextromethorphan + Pinacidil DC9ZPX4 Dextromethorphan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Aprepitant DCYQ7BJ Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Meclofenamic acid DC6MQA8 Meclofenamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Ribavirin-TP DCIPPXR Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Sertraline DCAKMOY Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Baclofen DCIMY85 Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Primidone DC4ZDP4 Primidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Diethylcarbamazine DCFCBVB Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Citalopram DCX01KO Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Dactinomycin DCUV90J Dactinomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Furazolidone DCHGW9Y Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Chlorphenesin DC700O8 Chlorphenesin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Everolimus DC01LZV Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Tranexamic acid DCI2WWE Tranexamic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + 10-hydroxycamptothecin DCEU750 10-hydroxycamptothecin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + IT-141 DCTY8LO IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Palonosetron DCM11VL Palonosetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Metyrosine DC5WA4D Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Terameprocol DC79ATL Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Guanfacine DCRLSZC Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Amodiaquine DCJJP17 Amodiaquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Itraconazole DC29K6P Itraconazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Doxapram DC23KQU Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + K-134 DCS1CW0 K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Memantine DCWOYA3 Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Phenprocoumon DCKK30R Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Pazopanib DCBAR2U Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Daidzin DCSOJH8 Daidzin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Phensuximide DCHXXPO Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Fluspirilene DCSKXWQ Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Armodafinil DC7W7NR Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Ciprofibrate DCWRSW7 Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Nizatidine DCXGG3H Nizatidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Naringenin DC88BB4 Naringenin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Triflupromazine DC80AA0 Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Niclosamide DCISBKS Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Trazodone DCJ9SSA Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Isoproterenol DCD0FID Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Trifluoperazine DCUYAAW Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Tiagabine DC3K46K Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Diazoxide DCWLP77 Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Allopurinol DCK5J3U Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Imatinib DCVX1CS Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Probenecid DC3G7QO Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Pramipexole DCQVYU2 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Methylene blue DC2M63R Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Oxyphenbutazone DC7CFYU Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Acetohexamide DC9RC1O Acetohexamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Leflunomide DCQ8UVE Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Novobiocin DC0HLU6 Novobiocin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Chlorambucil DCSUQ5J Chlorambucil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Brincidofovir DCFKQ3U Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Amantadine DCFWHNG Amantadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Sorafenib DCN7N3R Sorafenib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Quinine DCQI8CS Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Mycophenolic acid DCCFQ8B Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Hydralazine DCBOC33 Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Iloprost DCCNSQH Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Nabilone DCC6C7B Nabilone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Olmesartan medoxomil DCNKVB1 Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + PMID28870136-Compound-43 DCSO1VK PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Cevimeline DCA0C8P Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Estramustine DC33BVW Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Cerivastatin DCAFXOO Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Hydroxychloroquine DCFI6AQ Hydroxychloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Atovaquone DCOKUMT Atovaquone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + ML323 DC0V93Q ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Aciclovir DCU6ASJ Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Enoxacin DC4IQ7C Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Raltegravir DCU1G8A Raltegravir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Albendazole DCDYRRM Albendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Tacrolimus DCE19E1 Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Tetracycline DC4QG5J Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Cytarabine DCF1SKX Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Etomidate DCRTG3L Etomidate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 75 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2412).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.