Details of the Drug Combinations

General Information of This Drug (ID: DMRKXPT)

• Drug Name: Ketoprofen (DMRKXPT)
• Synonyms: Actron; Alrheumat; Alrheumum; Alrheumun; Aneol; Capisten; Dexal; Epatec; Fastum; Kefenid; Ketoprofene; Ketoprofeno; Ketoprofenum; Ketopron; Ketoprophene; Lertus; Menamin; Meprofen; Orudis; Orugesic; Oruvail; Oscorel; Profenid; Toprec; Toprek; Benzoylhydratropic Acid; Orudis KT; K 1751; RP 19583; RP19583; RU 4733; Arthril (TN); Fastum (TN); Fastum Gel (TN); Iso-K; Keto (TN); Ketoflam (TN); Ketomex (TN); Ketonal (TN); Ketoprofenas (TN); Ketoprofene (TN); Ketoprofene [INN-French]; Ketoprofeno [INN-Spanish]; Ketoprofenum (TN); Ketoprofenum [INN-Latin]; Ketorin (TN); Ketospray (TN); Lasonil (TN); M-Benzoylhydratropic acid; Oki (TN); Orudis (TN); Oruvail (TN); RP-19583; Racemic-Ketoprofen; Zon (TN); Bi-Profnid (TN); RP, 19,583; Ketoprofen (JP15/USP/INN); Ketoprofen [USAN:INN:BAN:JAN]; Orudis, Oruvail, Ketoflam, Orudis KT, Ketoprofen; Acide (benzoyl-3-phenyl)-2-propionique; Acide (benzoyl-3-phenyl)-2-propionique [French]; L'Acide (benzoyl-3-phenyl)-2-propionique; (+-)-m-Benzoylhydratropic acid; 2-(3-Benzoylphenyl)propanoic acid; 2-(3-Benzoylphenyl)propionic acid; 2-(m-Benzoylphenyl)propionic acid; 2-[3-(benzoyl)phenyl]propanoic acid; 2-[3-(phenylcarbonyl)phenyl]propanoic acid; 2-[3-Benzoylphenyl]propionic acid; 3-Benzoylhydratropic acid

Indication

Bursitis; ICD 11: N.A.; Status: Approved [1]; Dysmenorrhea; ICD 11: GA34.3; Status: Approved [1]; Musculoskeletal pain; ICD 11: MG30; Status: Approved [2]; Pain; ICD 11: MG30-MG3Z; Status: Phase 3 [3]; Migraine; ICD 11: 8A80; Status: Phase 2 [4]; Osteoarthritis; ICD 11: FA00-FA05; Status: Phase 1 [4]

• Therapeutic Class: Analgesics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ketoprofen + Amoxicillin	DCSB80R	Amoxicillin	Pharyngotonsillitis	[5]
Metoclopramide + Ketoprofen	DC9YN1O	Metoclopramide	Migraine	[6]
Ketoprofen + Morphine	DC8GLA3	Morphine	Pain, Postoperative	[7]

References

• [1] Ketoprofen FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4795).
• [3] Ketoprofen-induced cyclooxygenase inhibition in renal medulla and platelets of rats treated with caffeine. Pharmacology. 2001;63(4):234-9.
• [4] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [5] ClinicalTrials.gov (NCT00799838) Evaluation of Inflammatory Symptoms Reduction With Amoxicillin + Ketoprofen in Acute Pharyngeal Tonsillitis in Pediatric Patients
• [6] ClinicalTrials.gov (NCT00557544) Trial on Metoclopramide and Ketoprofen in Acute Migraine of Childhood
• [7] ClinicalTrials.gov (NCT02248493) Intravenous Paracetamol for Postoperative Pain