Details of the Drug Combinations

General Information of This Drug (ID: DMRQD04)

• Drug Name: Tramadol (DMRQD04)
• Synonyms: Conzip; Ryzolt; Tramadol Hydrochloride; Ultram Er; Rybix Odt; Ultram

Indication

Osteoarthritis; ICD 11: FA00-FA05; Status: Approved [1]; Pain; ICD 11: MG30-MG3Z; Status: Approved [2]; Chronic pain; ICD 11: MG30; Status: Investigative [1]; Premature ejaculation; ICD 11: HA03.0Z; Status: Investigative [1]

• Therapeutic Class: Analgesics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

23 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Capsaicin + Tramadol	DC23QD8	Capsaicin	Or Peripheral Nerve Injury (PNI)	[3]
Duloxetine + Tramadol	DCG4Z0O	Duloxetine	Diabetic Polyneuropathy	[4]
Duloxetine + Tramadol	DCS0HSJ	Duloxetine	Cancer Pain	[5]
Heparin + Tramadol	DCDTSG1	Heparin	Second Degree Burns	[6]
Ketorolac + Tramadol	DCDPW4T	Ketorolac	Arthritis Knee	[7]
Lidocaine + Tramadol	DC8NYX7	Lidocaine	Pulpitis	[8]
Metamizole + Tramadol	DCXEDGK	Metamizole	Lumbar Disc Disease	[9]
Pregabalin + Tramadol	DCOAPPT	Pregabalin	Diabetic Polyneuropathy	[4]
Tramadol + Oxycodone	DC69S9M	Oxycodone	Osteo Arthritis Knee	[10]
Tramadol + Acetaminophen	DCAP16F	Acetaminophen	Lumbar Disc Herniation	[11]
Tramadol + Acetaminophen	DCOIEJK	Acetaminophen	Pain	[12]
Buprenorphine + Tramadol	DCMT3Q9	Buprenorphine	Head and Neck Squamous Cell Carcinoma	[13]
Hydrocodone + Tramadol	DC0G5CJ	Hydrocodone	Intra-abdominal Cancer	[14]
Metoclopramide + Tramadol	DCYEKD5	Metoclopramide	Trauma	[15]
Tramadol + Naproxen	DC38CP4	Naproxen	Acute Pain	[16]
Tramadol + Acetaminophen	DCDJ581	Acetaminophen	Muscle Weakness	[17]
Amitriptyline + Tramadol	DCV5U6U	Amitriptyline	Pain, Neuropathic	[18]
Lidocaine + Tramadol	DCJVZWT	Lidocaine	Pain Management	[19]
Metamizole + Tramadol	DCCDEJ4	Metamizole	Chronic Pain Due to Trauma	[20]
Levobupivacaine + Tramadol	DCWMSM7	Levobupivacaine	Heart Surgery Via Sternotomy	[21]
Morphine + Tramadol	DCSACKG	Morphine	Postoperative Pain	[22]
Sildenafil + Tramadol	DCTYZ84	Sildenafil	Premature Ejaculation	[23]
Tramadol + Naproxen	DC5O2LG	Naproxen	Osseointegrated Dental Implantation	[24]

References

• [1] Tramadol FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8286).
• [3] ClinicalTrials.gov (NCT01416116) Method of Pre-treatment for Application of QUTENZA Capsaicin 8% Patch
• [4] ClinicalTrials.gov (NCT01116531) Efficacy, Safety, Tolerability and Pharmacokinetics of Concomitant Administration of Tramadol With Duloxetine or Pregabalin
• [5] ClinicalTrials.gov (NCT05311774) Efficacy of Duloxetine in Conjunction With Tramadol for Chronic Cancer Pain
• [6] ClinicalTrials.gov (NCT02497326) Heparin for the Treatment of Burn Wound Pain
• [7] ClinicalTrials.gov (NCT06112548) The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA
• [8] ClinicalTrials.gov (NCT05538052) Use of Tramadol Intraligamentary Injections
• [9] ClinicalTrials.gov (NCT02971540) SPI-directed Analgesia for Lumbar Discectomy
• [10] ClinicalTrials.gov (NCT04003350) The Effect of Prolonged Multimodal Analgesic Regimen on Post Hospital Discharge Opioid Use and Pain Control After Primary Total Knee Arthroplasty
• [11] ClinicalTrials.gov (NCT03482492) Tramadol vs.Tramadol With Paracetamol
• [12] ClinicalTrials.gov (NCT00766675) An Efficacy Study of Combination of Tramadol and Acetaminophen Tablets in the Treatment of Participants With Fibromyalgia Pain
• [13] ClinicalTrials.gov (NCT04752384) Transdermal Buprenorphine for the Treatment of Radiation-Induced Mucositis Pain in Head and Neck Cancer Patients
• [14] ClinicalTrials.gov (NCT06232577) 5x-Multiplier vs 3-Tier Model for Discharge Opioid Prescriptions After Intra-abdominal Cancer Surgery: A Randomized Clinical Trial
• [15] ClinicalTrials.gov (NCT03383315) Role of Prophylactic Metoclopramide With Tramadol in Trauma Patients
• [16] ClinicalTrials.gov (NCT05995912) Efficacy and Safety of Etoricoxib-tramadol Tablet in Acute Postoperative Pain
• [17] ClinicalTrials.gov (NCT03496389) Does Gabapentin Reduce Quadriceps Muscle Weakness After Anterior Cruciate Ligament Reconstruction?
• [18] ClinicalTrials.gov (NCT03324035) Treatment of Neuropathic Pain in Leprosy
• [19] ClinicalTrials.gov (NCT05928520) Pain Management in Pediatric Adenotonsillectomy
• [20] ClinicalTrials.gov (NCT03255330) The Effect of Gabapentin Used as a Preemptive to the Emergence and Development Chronic Neuropathic Pain in Patients After Spinal Cord Trauma
• [21] ClinicalTrials.gov (NCT02851394) Advantage of Tramadol in Local Analgesia Post-Sternotomy
• [22] ClinicalTrials.gov (NCT05956275) USG-Guided Infiltration Popliteal Artery Capsule Knee Block Versus Adductor Canal Block Application as Postoperative Analgesia
• [23] ClinicalTrials.gov (NCT05183334) Combined On-demand Sildenafil Citrate and Tramadol Hydrochloride for Treatment of Premature Ejaculation
• [24] ClinicalTrials.gov (NCT04694300) OTC Naproxen and Acetaminophen Anti-Inflammatory Action in Dental Implant Patients