Details of the Drug Combinations

General Information of This Drug (ID: DMRSNEU)

Drug Name

Masitinib DMRSNEU

Synonyms

Masitinib; 790299-79-5; AB1010; Masatinib; Masitinib (AB1010); Masivet; AB-1010; AB 1010; UNII-M59NC4E26P; Masitinib [INN]; M59NC4E26P; 4-[(4-Methyl-1-piperazinyl)methyl]-N-[4-methyl-3-[[4-(3-pyridinyl)-2-thiazolyl]amino]phenyl]benzamide; CHEMBL1908391; CHEBI:63450; Masitinib (INN); N-(4-Methyl-3-((4-(pyridin-3-yl)thiazol-2-yl)amino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide; Q-201339; C28H30N6OS; N-(4-methyl-3-(4-(pyridin-3-yl)thiazol-2-ylamino)phenyl)-4-((4-methylpiperazin-1-yl)methyl)benzamide

Indication

Disease Entry	ICD 11	Status	REF
Amyotrophic lateral sclerosis	8B60.0	Phase 3	[1]
Gastrointestinal stromal tumour	2B5B	Phase 3	[2]
Metastatic gastric or gastroesophageal junction cancer	2D8Y	Phase 3	[1]
Multiple sclerosis	8A40	Phase 3	[3]
Ovarian cancer	2C73	Phase 3	[2]
Pancreatic cancer	2C10	Phase 3	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Gemcitabine + Masitinib	DCBIZ1V	Gemcitabine	Pancreatic Cancer	[4]
Gemcitabine + Masitinib	DCIZGP5	Gemcitabine	Ovarian Cancer	[5]
Riluzole + Masitinib	DCSL9MN	Riluzole	Amyotrophic Lateral Sclerosis (ALS)	[6]
Riluzole + Masitinib	DCGNGNK	Riluzole	Amyotrophic Lateral Sclerosis	[7]
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References

1	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
2	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
3	Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4	ClinicalTrials.gov (NCT00789633) Masitinib in Combination With Gemcitabine for Treatment of Patients With Advanced/Metastatic Pancreatic Cancer
5	ClinicalTrials.gov (NCT02490488) Masitinib in Combination With Gemcitabine in Advanced/Metastatic Epithelial Ovarian Cancer Patients
6	ClinicalTrials.gov (NCT02588677) Masitinib in Combination With Riluzole for the Treatment of Patients Suffering From Amyotrophic Lateral Sclerosis (ALS)
7	ClinicalTrials.gov (NCT03127267) Efficacy and Safety of Masitinib Versus Placebo in the Treatment of ALS Patients