Details of the Drug Combinations

General Information of This Drug (ID: DMRWD63)

Drug Name

FRAX-120 DMRWD63

Synonyms

FRAX-355; FRAX-486; P21-activated kinase inhibitor (central nervous system disorders), Afraxis; P21-activated kinase inhibitors (central nervous system disorders/cancer); P21-activated kinase inhibitors (central nervous system disorders/cancer), Afraxis

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Investigative	[1]
------------------------------------------------------------------------------------

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
FRAX-120 + Panobinostat	DC7JRPQ	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
------------------------------------------------------------------------------------

References

1	The ChEMBL database in 2017. Nucleic Acids Res. 2017 Jan 4;45(D1):D945-D954.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.