Details of the Drug Combinations

General Information of This Drug (ID: DMS2Q9G)

Drug Name

PHA848125 DMS2Q9G

Synonyms

Milciclib; PHA-848125; 802539-81-7; PHA 848125; Milciclib (PHA-848125); UNII-688000M8S8; PHA848125; MMV676602; 4,5-dihydro-N,1,4,4-tetramethyl-8-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-1H-Pyrazolo[4,3-h]quinazoline-3-carboxamide; 688000M8S8; N,1,4,4-tetramethyl-8-(4-(4-methylpiperazin-1-yl)phenylamino)-4,5-dihydro-1H-pyrazolo[4,3-h]quinazoline-3-carboxamide; Milciclib [INN]; N,1,4,4-Tetramethyl-8-{[4-(4-Methylpiperazin-1-Yl)phenyl]amino}-4,5-Dihydro-1h-Pyrazolo[4,3-H]quinazoline-3-Carboxamide

Indication

Disease Entry	ICD 11	Status	REF
Thymic cancer	2C27	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

12 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
C646 + PHA848125	DCSHC34	C646	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Doxorubicin + PHA848125	DC4TVZN	Doxorubicin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Gemcitabine + PHA848125	DCURWEF	Gemcitabine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Mebendazole + PHA848125	DC9DSYZ	Mebendazole	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Palbociclib + PHA848125	DCIFUAV	Palbociclib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
PHA848125 + Buparlisib	DCJINQW	Buparlisib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
PHA848125 + JQ1	DCXU8V3	JQ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
PHA848125 + RTB101	DC3DZNI	RTB101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
PHA848125 + BMS-754807	DCHMSDZ	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
PHA848125 + THZ1	DCIMDPG	THZ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
PHA848125 + CB3304	DCDDNP7	CB3304	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
PHA848125 + E7820	DCUJH7X	E7820	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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⏷ Show the Full List of 12 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7938).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.