Details of the Drug Combinations

General Information of This Drug (ID: DMT0YQI)

Drug Name

8-chloro-adenosine DMT0YQI

Synonyms

Nucleoside analogs (cancer); Nucleoside analogs (cancer), MD Anderson Cancer Center; 8-Cl-Ado

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
8-chloro-adenosine + Idarubicin	DCAI59B	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
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1 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Venetoclax + 8-chloro-adenosine	DCE32LR	Venetoclax	Acute Myeloid Leukemia	[3]
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References

1	ClinicalTrials.gov (NCT02509546) 8-Chloro-Adenosine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	ClinicalTrials.gov (NCT05263284) 8-Chloroadenosine in Combination With Venetoclax for the Treatment of Patients With Relapsed/Refractory Acute Myeloid Leukemia