Details of the Drug Combinations

General Information of This Drug (ID: DMT3D5I)

Drug Name
Aflibercept   DMT3D5I
Synonyms Ziv-Aflibercept; Zaltrap (TN); VEGF Trap; VEGF Trap-Eye
Indication
Disease Entry ICD 11 Status REF
Central retinal vein occlusion with macular edema N.A. Approved [1]
Diabetic macular edema 9B71.02 Approved [2]
Exudative age-related macular degeneration 9B78.3Z Approved [3]
Metastasis from malignant tumor of colon N.A. Approved [4]
Metastatic colorectal cancer 2B91 Approved [5]

List of Combinatorial Drugs (CBD) Containing This Drug

13 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Aflibercept + Capecitabine DCSYKQV Capecitabine Metastatic Colorectal Cancers [6]
Axitinib + Aflibercept DCNGTTW Axitinib Neovascular Age-related Macular Degeneration [7]
Docetaxel + Aflibercept DCL2NZG Docetaxel Neoplasms [8]
Docetaxel + Aflibercept DCP7BKB Docetaxel Neoplasm Malignant [9]
Gemcitabine + Aflibercept DCYMOOT Gemcitabine Pancreatic Neoplasm [10]
Indocyanine green + Aflibercept DCPQ3TA Indocyanine green Polypoidal Choroidal Vasculopathy [11]
Nesvacumab + Aflibercept DCDL0DM Nesvacumab Diabetic macular edema [12]
Oxaliplatin + Aflibercept DCUA8H4 Oxaliplatin Rectal Cancer [13]
Oxaliplatin + Aflibercept DCSKBNL Oxaliplatin Colorectal Cancer Metastatic [14]
Temozolomide + Aflibercept DCKCJL0 Temozolomide Adult Anaplastic Astrocytoma [15]
Verteporfin + Aflibercept DCREGW2 Verteporfin Macular Degeneration [16]
Salicylhydroxamic acid + Aflibercept DC9QBQT Salicylhydroxamic acid Exudative Age-related Macular Degeneration [17]
Salicylhydroxamic acid + Aflibercept DCTMP0Y Salicylhydroxamic acid Neovascular Age-related Macular Degeneration [18]
------------------------------------------------------------------------------------
⏷ Show the Full List of 13 DrugCom(s)

References

1 A review of neovascular glaucoma. Etiopathogenesis and treatment. Rom J Ophthalmol. 2021 Oct-Dec;65(4):315-329.
2 Aflibercept versus Faricimab in the Treatment of Neovascular Age-Related Macular Degeneration and Diabetic Macular Edema: A Review. Int J Mol Sci. 2022 Aug 20;23(16):9424.
3 Efficacy and Safety of Intravitreal Aflibercept Treat-and-Extend Regimens in Exudative Age-Related Macular Degeneration: 52- and 96-Week Findings from ALTAIR : A Randomized Controlled Trial. Adv Ther. 2020 Mar;37(3):1173-1187.
4 A Comparison of Folinic Acid, Fluorouracil and Irinotecan (FOLFIRI) plus Bevacizumab and FOLFIRI plus Aflibercept as Second-line Treatment for Metastatic Colorectal Cancer. Clin Oncol (R Coll Radiol). 2022 Aug;34(8):e323-e328.
5 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
6 ClinicalTrials.gov (NCT01843725) Phase 1 Study Testing the Combination of Aflibercept and Capecitabine in Metastatic Digestive and Breast Cancers
7 ClinicalTrials.gov (NCT04626128) Safety and Tolerability Study of Suprachoroidal Injection of CLS-AX Following Anti-VEGF Therapy in Neovascular AMD
8 ClinicalTrials.gov (NCT00545246) A Phase I Study of Intravenous Aflibercept in Combination With Docetaxel in Japanese Cancer Patients
9 ClinicalTrials.gov (NCT01148615) A Study of Intravenous Aflibercept With Docetaxel in Chinese Patients With Solid Tumors
10 ClinicalTrials.gov (NCT00574275) Aflibercept Compared to Placebo in Term of Efficacy in Patients Treated With Gemcitabine for Metastatic Pancreatic Cancer
11 ClinicalTrials.gov (NCT02597855) Short-term Efficacy of Intravitreal Afilibercept Depending on Subtypes of Polypoidal Choroidal Vasculopathy: Polypoidal Choroidal Neovascularization or Idiopathic Choroidal Vasculopathy
12 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
13 ClinicalTrials.gov (NCT01749956) 5-FU, Aflibercept, and Radiation (RT) for Preoperative and Postoperative Patients With Stage II/III Rectal Cancer
14 ClinicalTrials.gov (NCT01955629) Study of Aflibercept as Maintenance Therapy Following Induction With Aflibercept in Combination With XELOX, as First-Line Treatment for Metastatic Colorectal Cancer Patient
15 ClinicalTrials.gov (NCT00650923) Aflibercept, Radiation Therapy, and Temozolomide in Treating Patients With Newly Diagnosed or Recurrent Glioblastoma Multiforme, Gliosarcoma, or Other Malignant Glioma
16 ClinicalTrials.gov (NCT01746875) A Study Testing if Medicine Can Make Pigment Epithelium Detachments Regress and Stabilize the Vision in Eyes
17 ClinicalTrials.gov (NCT04200248) A Phase II Study of RBM-007 Alone and RBM-007 With Eylea in Subjects With Wet Age-related Macular Degeneration
18 ClinicalTrials.gov (NCT04684394) A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Neovascular Age-related Macular Degeneration