Details of the Drug Combinations

General Information of This Drug (ID: DMT70RC)

Drug Name
Piperaquine   DMT70RC
Synonyms
Piperaquinoline; Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-); Quinoline, 4,4'-(1,3-propanediyldi-4,1-piperazinediyl)bis(7-chloro-(9CI); 1,3-bis(1-(7-chloro-4'-quinolyl)-4'-piperazinyl)propane; 1,3-bis(4-(7'-chloro-4'-quinoline)-1-piperazine); 4,4'-(propane-1,3-diyldipiperazine-4,1-diyl)bis(7-chloroquinoline); 7-chloro-4-[4-[3-[4-(7-chloroquinolin-4-yl)piperazin-1-yl]propyl]piperazin-1-yl]quinoline
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

88 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
AC265347 + Piperaquine DCKVV8I AC265347 DD2 (Cell Line: DD2) [2]
Alvespimycin hydrochloride + Piperaquine DCBOLZK Alvespimycin hydrochloride DD2 (Cell Line: DD2) [2]
Alvespimycin hydrochloride + Piperaquine DCE0C2J Alvespimycin hydrochloride Hepatoblastoma (Cell Line: HB3) [3]
Atovaquone + Piperaquine DCR7HR4 Atovaquone DD2 (Cell Line: DD2) [2]
Atovaquone + Piperaquine DCRRKSK Atovaquone Hepatoblastoma (Cell Line: HB3) [2]
Azelnidipine + Piperaquine DCT27DK Azelnidipine Hepatoblastoma (Cell Line: HB3) [2]
Bafilomycin A1 + Piperaquine DC149GM Bafilomycin A1 DD2 (Cell Line: DD2) [2]
Bafilomycin A1 + Piperaquine DC087JS Bafilomycin A1 Hepatoblastoma (Cell Line: HB3) [3]
Benzamil + Piperaquine DC88KKL Benzamil DD2 (Cell Line: DD2) [2]
Berberine + Piperaquine DC7S6PH Berberine DD2 (Cell Line: DD2) [2]
BGT226 + Piperaquine DCE0WIV BGT226 DD2 (Cell Line: DD2) [2]
BGT226 + Piperaquine DCHCEBF BGT226 Hepatoblastoma (Cell Line: HB3) [3]
Biperiden + Piperaquine DCTPHQF Biperiden DD2 (Cell Line: DD2) [2]
Biperiden + Piperaquine DCD4W8U Biperiden Hepatoblastoma (Cell Line: HB3) [3]
BIX-01294 + Piperaquine DCRFU87 BIX-01294 DD2 (Cell Line: DD2) [2]
Bumetanide + Piperaquine DC0Y3ZL Bumetanide DD2 (Cell Line: DD2) [2]
Calmidazolium + Piperaquine DCNZPYC Calmidazolium Hepatoblastoma (Cell Line: HB3) [3]
Carfilzomib + Piperaquine DCG3TC1 Carfilzomib DD2 (Cell Line: DD2) [2]
Carfilzomib + Piperaquine DCIDVLM Carfilzomib Hepatoblastoma (Cell Line: HB3) [2]
Chloroquine + Piperaquine DCNUB4H Chloroquine Hepatoblastoma (Cell Line: HB3) [2]
Clindamycin + Piperaquine DCWDFCY Clindamycin DD2 (Cell Line: DD2) [2]
Clindamycin + Piperaquine DC8P8XE Clindamycin Hepatoblastoma (Cell Line: HB3) [2]
Clomiphene citrate + Piperaquine DCFKX0H Clomiphene citrate DD2 (Cell Line: DD2) [2]
Clomiphene citrate + Piperaquine DC5R5PP Clomiphene citrate Hepatoblastoma (Cell Line: HB3) [3]
Cycloheximide + Piperaquine DC3D3U6 Cycloheximide DD2 (Cell Line: DD2) [2]
Cycloheximide + Piperaquine DC2F0LE Cycloheximide Hepatoblastoma (Cell Line: HB3) [3]
Doxycycline + Piperaquine DC12XST Doxycycline DD2 (Cell Line: DD2) [2]
Emetine + Piperaquine DCP8ZZH Emetine DD2 (Cell Line: DD2) [2]
Emetine + Piperaquine DCPJP2X Emetine Hepatoblastoma (Cell Line: HB3) [3]
Eszopiclone + Piperaquine DCBR1AO Eszopiclone DD2 (Cell Line: DD2) [2]
Eszopiclone + Piperaquine DC009XW Eszopiclone Hepatoblastoma (Cell Line: HB3) [3]
Fendiline + Piperaquine DCSTU4Q Fendiline Hepatoblastoma (Cell Line: HB3) [3]
Gentian violet + Piperaquine DCMQB7E Gentian violet Hepatoblastoma (Cell Line: HB3) [3]
Gliclazide + Piperaquine DCI6A85 Gliclazide DD2 (Cell Line: DD2) [2]
GNF-PF-5411 + Piperaquine DC5S4G3 GNF-PF-5411 DD2 (Cell Line: DD2) [2]
GSK2126458 + Piperaquine DC1GL5L GSK2126458 DD2 (Cell Line: DD2) [2]
KN-62 + Piperaquine DCM84DP KN-62 DD2 (Cell Line: DD2) [2]
KN-62 + Piperaquine DCEYGGX KN-62 Hepatoblastoma (Cell Line: HB3) [3]
Lidoflazine + Piperaquine DCSY42P Lidoflazine DD2 (Cell Line: DD2) [2]
Lumefantrine + Piperaquine DCZP7LM Lumefantrine DD2 (Cell Line: DD2) [2]
Lumefantrine + Piperaquine DCZ8HQQ Lumefantrine Hepatoblastoma (Cell Line: HB3) [2]
Mefloquine + Piperaquine DC6YLK3 Mefloquine DD2 (Cell Line: DD2) [2]
Mefloquine + Piperaquine DCNO7DQ Mefloquine Hepatoblastoma (Cell Line: HB3) [2]
Methotrexate + Piperaquine DC8KR49 Methotrexate DD2 (Cell Line: DD2) [2]
Methotrexate + Piperaquine DC8EDXT Methotrexate Hepatoblastoma (Cell Line: HB3) [2]
Methylene blue + Piperaquine DCHCP3A Methylene blue DD2 (Cell Line: DD2) [2]
Methylene blue + Piperaquine DCSVNK3 Methylene blue Hepatoblastoma (Cell Line: HB3) [3]
Miconazole + Piperaquine DCR516Y Miconazole Hepatoblastoma (Cell Line: HB3) [3]
Midostaurin + Piperaquine DCJ3LJ7 Midostaurin DD2 (Cell Line: DD2) [2]
Midostaurin + Piperaquine DCSFOHC Midostaurin Hepatoblastoma (Cell Line: HB3) [3]
MK-3207 + Piperaquine DCM13K5 MK-3207 DD2 (Cell Line: DD2) [2]
Naltrexone + Piperaquine DCFYA5K Naltrexone Hepatoblastoma (Cell Line: HB3) [2]
Nisoldipine + Piperaquine DCYTMGF Nisoldipine DD2 (Cell Line: DD2) [2]
NITD609 + Piperaquine DCLM5CM NITD609 Hepatoblastoma (Cell Line: HB3) [3]
Otilonium bromide + Piperaquine DCC18RO Otilonium bromide Hepatoblastoma (Cell Line: HB3) [2]
Panobinostat + Piperaquine DCFJUH8 Panobinostat DD2 (Cell Line: DD2) [2]
PD-0173955 + Piperaquine DC3W8Q4 PD-0173955 DD2 (Cell Line: DD2) [2]
PD-0173955 + Piperaquine DC0964D PD-0173955 Hepatoblastoma (Cell Line: HB3) [3]
Perhexiline + Piperaquine DC8FN67 Perhexiline DD2 (Cell Line: DD2) [2]
Piperaquine + OZ277 DCH9CG0 OZ277 DD2 (Cell Line: DD2) [2]
Piperaquine + Lumefantrine DCYC30O Lumefantrine DD2 (Cell Line: DD2) [2]
Piperaquine + Artemether DC05DK4 Artemether DD2 (Cell Line: DD2) [2]
Piperaquine + Benzamil DCJ7YQF Benzamil DD2 (Cell Line: DD2) [2]
Piperaquine + Panobinostat DC1SUP1 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Piperaquine + Plinabulin DC1B89Z Plinabulin Glioblastoma (Cell Line: JHH-136) [2]
Piperaquine + GDC-0980/RG7422 DC6JRID GDC-0980/RG7422 Glioblastoma (Cell Line: JHH-136) [2]
Piperaquine + OSI-027 DCVX1HJ OSI-027 Glioblastoma (Cell Line: JHH-136) [2]
Piperaquine + Methylene blue DCBA2E5 Methylene blue DD2 (Cell Line: DD2) [2]
Piperaquine + Mebendazole DC4T3YC Mebendazole Glioblastoma (Cell Line: JHH-136) [2]
Piperaquine + Chloroquine DCQV5VY Chloroquine DD2 (Cell Line: DD2) [2]
Piperaquine + Atovaquone DCLS5SZ Atovaquone DD2 (Cell Line: DD2) [2]
Piperaquine + Calindol DC618K3 Calindol DD2 (Cell Line: DD2) [2]
Piperaquine + OZ277 DCOZHPF OZ277 Hepatoblastoma (Cell Line: HB3) [3]
Piperaquine + Lumefantrine DC1EN2X Lumefantrine Hepatoblastoma (Cell Line: HB3) [3]
Piperaquine + Artemether DC7TA72 Artemether Hepatoblastoma (Cell Line: HB3) [3]
Piperaquine + Tetrandrine DCP0YM1 Tetrandrine Hepatoblastoma (Cell Line: HB3) [3]
Piperaquine + Artemisinin DCYK4QG Artemisinin Hepatoblastoma (Cell Line: HB3) [3]
Piperaquine + Omacetaxine mepesuccinate DCZG3L1 Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [3]
Piperaquine + Atovaquone DC8PYDC Atovaquone Hepatoblastoma (Cell Line: HB3) [3]
Proguanil + Piperaquine DCBBIX5 Proguanil DD2 (Cell Line: DD2) [2]
Pyronaridine + Piperaquine DCK5TJ3 Pyronaridine DD2 (Cell Line: DD2) [2]
Quinine + Piperaquine DCHU3L6 Quinine DD2 (Cell Line: DD2) [2]
Sapanisertib + Piperaquine DCP981J Sapanisertib DD2 (Cell Line: DD2) [2]
Sitosterol + Piperaquine DCOJHXV Sitosterol Hepatoblastoma (Cell Line: HB3) [3]
TG100-115 + Piperaquine DC66ITC TG100-115 DD2 (Cell Line: DD2) [2]
Topiramate + Piperaquine DCTEVAT Topiramate DD2 (Cell Line: DD2) [2]
Trichostatin A + Piperaquine DC28Y6K Trichostatin A DD2 (Cell Line: DD2) [2]
Vinpocetine + Piperaquine DCLZWE0 Vinpocetine DD2 (Cell Line: DD2) [2]
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⏷ Show the Full List of 88 DrugCom(s)

References

1 The fight against drug-resistant malaria: novel plasmodial targets and antimalarial drugs. Curr Med Chem. 2008;15(2):161-71.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.