Details of the Drug Combinations

General Information of This Drug (ID: DMT9K8G)

• Drug Name: Raltitrexed (DMT9K8G)
• Synonyms: Tomudex; 112887-68-0; ZD1694; ZD-1694; ICI-D1694; D-1694; ZD 1694; ICI D1694; UNII-FCB9EGG971; D1694; D 1694; CHEBI:5847; Raltitrexed (Tomudex); C21H22N4O6S; ZD-16; (2S)-2-[[5-[methyl-[(2-methyl-4-oxo-1H-quinazolin-6-yl)methyl]amino]thiophene-2-carbonyl]amino]pentanedioic acid; FCB9EGG971; CHEMBL225071; N-(5-(N-(3,4-Dihydro-2-methyl-4-oxoquinazolin-6-ylmethyl)-N-methylamino)-2-thenoyl)-L-glutamic acid; ICI-D-1694; NSC-639186; NCGC00229704-01; DSSTox_RID_81653; DSSTox_CID_26482; DSSTox_GSID_46482

Indication

Rectal adenocarcinoma; ICD 11: 2B92; Status: Approved [1]

• Therapeutic Class: Anticancer Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Raltitrexed + Ibrutinib	DCYPFCW	Ibrutinib	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Lenvatinib + Raltitrexed	DCIF7BU	Lenvatinib	Hepatocellular Carcinoma Stage IIIa	[3]
Oxaliplatin + Raltitrexed	DCKEY5C	Oxaliplatin	Colorectal Cancer	[4]
Regorafenib + Raltitrexed	DC5BAEO	Regorafenib	Regorafenib	[5]
Irinotecan + Raltitrexed	DC38F49	Irinotecan	Colorectal Carcinoma	[6]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7403).
• [2] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [3] ClinicalTrials.gov (NCT05007587) Lenvatinib Plus HAIC of Modified FOLFOX Regime vs Lenvatinib Plus HAIC of ROX Regime in Patients With Advanced HCC
• [4] ClinicalTrials.gov (NCT01348412) Hepatic Arterial Chemotherapy With Raltitrexed and Oxaliplatin Versus Standard Chemotherapy in Unresectable Liver Metastases From Colorectal Cancer After Conventional Chemotherapy Failure
• [5] ClinicalTrials.gov (NCT05426811) Regorafenib Plus Raltitrexed as Third-line Treatment in Advanced Colorectal Cancer Patients
• [6] ClinicalTrials.gov (NCT02376452) Phase II Study of 2-weekly RAILIRI Versus FOLFIRI as Second-line Treatment in Advanced Colorectal Cancer Patients