Details of the Drug Combinations

General Information of This Drug (ID: DMTI8YE)

Drug Name

Bosutinib DMTI8YE

Synonyms

SKI 606; SKI606; Bosutinib (USAN); PF-5208763; SKI-606; Xy]-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methyl-1-piperazinyl)propoxy)-3-quinolinecarbonitrile; 4-((2,4-dichloro-5-methoxyphenyl)amino)-6-methoxy-7-(3-(4-methylpiperazin-1-yl)propoxy)quinoline-3-carbonitrile; 4-(2,4-dichloro-5-methoxyanilino)-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methyl-1-piperazinyl)propo; 4-[(2,4-dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(4-methylpiperazin-1-yl)propoxy]quinoline-3-carbonitrile; Bosutinib (BCR-ABL inhibitor 3rd gen)

Indication

Disease Entry	ICD 11	Status	REF
Blast phase chronic myelogenous leukemia, BCR-ABL1 positive	N.A.	Approved	[1]
Breast cancer	2C60-2C65	Approved	[2]
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Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Axitinib + Bosutinib	DC0NN1T	Axitinib	Accelerated Phase Chronic Myelogenous Leukemia (CML)	[3]
Bosutinib + Capecitabine	DCIN2ZE	Capecitabine	Advanced Breast Cancer (Parts 1 and 2)	[4]
Exemestane + Bosutinib	DC1KDX3	Exemestane	Advanced Breast Cancer	[5]
Letrozole + Bosutinib	DCROX04	Letrozole	Breast Cancer	[6]
Pemetrexed + Bosutinib	DCKCLGF	Pemetrexed	Carcinoma, Non-Small-Cell Lung	[7]
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References

1	Bosutinib FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5710).
3	ClinicalTrials.gov (NCT02782403) Axitinib and Bosutinib in Treating Patients With Chronic, Accelerated, or Blastic Phase Chronic Myeloid Leukemia
4	ClinicalTrials.gov (NCT00959946) Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic Breast Cancer
5	ClinicalTrials.gov (NCT00793546) Study Evaluating Bosutinib-Exemestane Combination Vs Exemestane Alone in Post Menopausal Women With Breast Cancer
6	ClinicalTrials.gov (NCT00880009) Study Evaluating Bosutinib-Letrozole Combination Versus Letrozole Alone In Post Menopausal Women With Breast Cancer
7	ClinicalTrials.gov (NCT03023319) Bosutinib in Combination With Pemetrexed in Patients With Selected Metastatic Solid Tumors