Details of the Drug Combinations

General Information of This Drug (ID: DMTO13J)

Drug Name

Clonazepam DMTO13J

Synonyms

Antelepsin; Antilepsin; Chlonazepam; Cloazepam; Clonazepamum; Clonex; Clonopin; Iktorivil; Kenoket; Klonopin; Landsen; Lktorivil; Lonazep; Melzap; Paxam; Ravotril; Rivatril; Rivoril; Rivotril; Solfidin; Klonopin Rapidly Disintegrating; DF2374250; RO4023; Ro 4023; Ro 54023; Alti-Clonazepam; Clonazepamum [INN-Latin]; Klonopin (TN); Ravotril (TN); Rivatril (TN); Rivotril (TN); Ro 4-8180; Ro 5-4023; Ro-5-4023; Clonazepam (JP15/USP/INN); Clonazepam [USAN:INN:BAN:JAN]; Ro 5-4023/B-7; 1,3-Dihydro-5-(o-chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2-one; 1,3-Dihydro-7-nitro-5-(2-chlorophenyl)-2H-1,4.benzodiazepin-2-one; 5-(2-Chloro-phenyl)-7-nitro-1,3-dihydro-benzo[e][1,4]diazepin-2-one; 5-(2-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 5-(2-Chlorophenyl)-7-nitro-3H-1,4-benzodiazepin-2(1H)-one; 5-(2-chlorophenyl)-7-nitro-1,3-dihydro-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-1,3-dihydro-7-nitro-2H-1,4-benzodiazepin-2-one; 5-(o-Chlorophenyl)-7-nitro-1H-1,4-benzodiazepin-2(3H)-one; 5-(o-chlorophenyl)-7-nitro-1,3-dihydro-2H-1,4-benzodiazepin-2-one; 7-Nitro-5-(2-chlorophenyl)-3H-1,4-benzodiazepin-2(1H)-one

Indication

Disease Entry	ICD 11	Status	REF
Absence epilepsy	N.A.	Approved	[1]
Epilepsy	8A60-8A68	Approved	[2]
Panic disorder	6B01	Approved	[1]
Seizure disorder	8A6Z	Phase 2	[2]
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Therapeutic Class

Anticonvulsants

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Sertraline + Clonazepam	DCLPQ24	Sertraline	Social Phobia	[3]
Sertraline + Clonazepam	DCQ4GA8	Sertraline	Panic Disorder	[4]
Fosphenytoin + Clonazepam	DC4OABL	Fosphenytoin	Status Epilepticus	[5]
Lorazepam + Clonazepam	DCK4JJ7	Lorazepam	Epilepsia Partialis Continua	[6]
Tolterodine + Clonazepam	DC2XDAZ	Tolterodine	Pain	[7]
Olanzapine + Clonazepam	DC0K3JK	Olanzapine	Suicide Crisis Syndrome	[8]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	Clonazepam FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6963).
3	ClinicalTrials.gov (NCT00282828) Improving Treatment Outcomes in Pharmacotherapy of Generalized Social Anxiety Disorder
4	ClinicalTrials.gov (NCT00118417) Therapies for Treatment-Resistant Panic Disorder Symptoms
5	ClinicalTrials.gov (NCT01870024) Comparison Between Lorazepam, Clonazepam and Clonazepam + Fosphenytoin for the Treatment of Out-of-hospital Generalized Status Epilepticus
6	ClinicalTrials.gov (NCT02134366) Clobazam Use in Epilepsia Partialis Continua - Pilot Study
7	ClinicalTrials.gov (NCT01011036) Effects of GABA-a-Agonists on Pain Mechanisms: An Experimental Study in Healthy Volunteers
8	ClinicalTrials.gov (NCT06133114) Psychopharmacological Treatment of Emotional Distress