Details of the Drug Combinations

General Information of This Drug (ID: DMTOUY9)

Drug Name

Suramin DMTOUY9

Synonyms

Antrypol; Belganyl; Farma; Fourneau; Germanin; Moranyl; Naganil; Naganin; Naganine; Naganol; Naphuride; SVR; Suramine; SURAMIN SODIUM; Sodium suramin; Suramine sodium; Farma 939; Naganol 6 Na; Germanin (TN); SGCTO-001

Indication

Disease Entry	ICD 11	Status	REF
African trypanosomiasis	1F51	Phase 1	[1]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Investigative	[2]
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Therapeutic Class

Antinematodal Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Suramin + SB-612111	DC4M05T	SB-612111	DD2 (Cell Line: DD2)	[3]
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2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Docetaxel + Suramin	DCITVH0	Docetaxel	Recurrent Non-small Cell Lung Cancer	[4]
Paclitaxel + Suramin	DCDCQ4Y	Paclitaxel	Recurrent Breast Cancer	[5]
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References

1	Arsenicals (Melarsoprol), Pentamidine and Suramin in the Treatment of Human African Trypanosomiasis. Parasitol Res. 2003 May;90(1):71-9.
2	Suramin, Penciclovir and Anidulafungin bind nsp12, which governs the RNA-dependent-RNA polymerase activity of SARS-CoV-2, with higher interaction energy than Remdesivir, indicating potential in the treatment of Covid-19 infection. April.21.2020. Doi: 10.31219/osf.io/urxwh
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	ClinicalTrials.gov (NCT00066768) Suramin and Either Docetaxel or Gemcitabine in Treating Patients With Stage IIIB or Stage IV Platinum-Refractory Non-Small Cell Lung Cancer
5	ClinicalTrials.gov (NCT00054028) Suramin and Paclitaxel in Treating Women With Stage IIIB-IV Breast Cancer