Details of the Drug Combinations

General Information of This Drug (ID: DMTV4L7)

Drug Name
CHS-828   DMTV4L7
Synonyms Cancer therapeutics, LEO Pharma; GMX-1778
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1/2 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

19 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + CHS-828 DCGXXAE (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [2]
ABT-263 + CHS-828 DCVE351 ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
CHS-828 + Carfilzomib DCSTHF3 Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
CHS-828 + Panobinostat DCXZIYB Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
CHS-828 + Eltanexor oral DCMBERR Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [2]
CHS-828 + Everolimus DCCVZXX Everolimus Ewing sarcoma (Cell Line: TC-71) [2]
CHS-828 + Daporinad DCS2EXP Daporinad Ewing sarcoma (Cell Line: TC-71) [2]
CHS-828 + AZD8330 DCHMCXD AZD8330 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
CHS-828 + Ruxolitinib DCWWS4M Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Daporinad + CHS-828 DC6GF3C Daporinad Ewing sarcoma (Cell Line: TC-71) [2]
Doxorubicin + CHS-828 DC4CWGL Doxorubicin Ewing sarcoma (Cell Line: TC-71) [2]
Evacetrapib + CHS-828 DCWVYOT Evacetrapib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Flucytosine + CHS-828 DC4JHV2 Flucytosine Embryonal rhabdomyosarcoma (Cell Line: CTR) [2]
Flucytosine + CHS-828 DCC68AB Flucytosine Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
JQ1 + CHS-828 DC8EPRF JQ1 Ewing sarcoma (Cell Line: TC-71) [2]
MK-1775 + CHS-828 DCUMDKR MK-1775 Ewing sarcoma (Cell Line: TC-71) [2]
OSI-906 + CHS-828 DCVLYUG OSI-906 Ewing sarcoma (Cell Line: TC-71) [3]
PHA-739358 + CHS-828 DCID0R0 PHA-739358 Ewing sarcoma (Cell Line: TC-71) [2]
Romidepsin + CHS-828 DCIZHXI Romidepsin Ewing sarcoma (Cell Line: TC-71) [2]
------------------------------------------------------------------------------------
⏷ Show the Full List of 19 DrugCom(s)

References

1 Anticancer agent CHS-828 inhibits cellular synthesis of NAD. Biochem Biophys Res Commun. 2008 Mar 21;367(4):799-804.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.