Details of the Drug Combinations

General Information of This Drug (ID: DMTYXQF)

Drug Name
NVP-AUY922   DMTYXQF
Synonyms
Luminespib; 747412-49-3; AUY922; VER-52296; AUY-922; UNII-C6V1DAR5EB; AUY922 (NVP-AUY922); Luminespib (NVP-AUY922); NVP-AUY 922; 5-(2,4-dihydroxy-5-isopropylphenyl)-N-ethyl-4-(4-(morpholinomethyl)phenyl)isoxazole-3-carboxamide; C6V1DAR5EB; Luminespib (AUY-922, NVP-AUY922); CHEBI:83656; 5-[2,4-DIHYDROXY-5-ISOPROPYLPHENYL]-N-ETHYL-4-[4-(4-MORPHOLINYLMETHYL)PHENYL]-3-ISOXAZOLECARBOXAMIDE; AK174786; 5-[2,4-Dihydroxy-5-(1-Methylethyl)phenyl]-N-Ethyl-4-[4-(Morpholin-4-Ylmethyl)phenyl]isoxazole-3-Carboxamide
Indication
Disease Entry ICD 11 Status REF
Multiple myeloma 2A83 Phase 2 [1]
Solid tumour/cancer 2A00-2F9Z Phase 2 [2]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

53 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
(-)-englerin A + NVP-AUY922 DCXUIBR (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [3]
ABT-263 + NVP-AUY922 DCSGUYD ABT-263 Ewing sarcoma (Cell Line: TC-71) [4]
Artemisinin + NVP-AUY922 DCLC8Q3 Artemisinin Hepatoblastoma (Cell Line: HB3) [3]
Atovaquone + NVP-AUY922 DCP2I2N Atovaquone Hepatoblastoma (Cell Line: HB3) [3]
Bardoxolone methyl + NVP-AUY922 DCT6CCI Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [3]
Everolimus + NVP-AUY922 DC0CH6X Everolimus Ewing sarcoma (Cell Line: TC-71) [3]
Gabapentin + NVP-AUY922 DCDS0BL Gabapentin Hepatoblastoma (Cell Line: HB3) [3]
GDC-0084 + NVP-AUY922 DC44D7V GDC-0084 Ewing sarcoma (Cell Line: TC-71) [3]
Lumefantrine + NVP-AUY922 DCQ8O8T Lumefantrine DD2 (Cell Line: DD2) [3]
Lumefantrine + NVP-AUY922 DCAMDLG Lumefantrine Hepatoblastoma (Cell Line: HB3) [3]
Mefloquine + NVP-AUY922 DCOM1R3 Mefloquine DD2 (Cell Line: DD2) [3]
Mefloquine + NVP-AUY922 DC1W540 Mefloquine Hepatoblastoma (Cell Line: HB3) [3]
MK-1775 + NVP-AUY922 DCWJYMY MK-1775 Ewing sarcoma (Cell Line: TC-71) [3]
MK-2206 + NVP-AUY922 DCCZCVB MK-2206 Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Buparlisib DC4UCKL Buparlisib Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Ombrabulin DCR3Y3T Ombrabulin Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + PD-0325901 DC7685M PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
NVP-AUY922 + Panobinostat DCFYDXL Panobinostat DD2 (Cell Line: DD2) [3]
NVP-AUY922 + Panobinostat DCP7YGF Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [3]
NVP-AUY922 + Alvespimycin hydrochloride DC34JFJ Alvespimycin hydrochloride DD2 (Cell Line: DD2) [3]
NVP-AUY922 + Eltanexor oral DCY074L Eltanexor oral Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Formononetin DCQN7JA Formononetin Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Everolimus DCXXRE3 Everolimus Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + GDC-0084 DCBB7UL GDC-0084 Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Lenvatinib DCJLPYK Lenvatinib Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Cantharidin DCMW68D Cantharidin Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Exherin DCY989O Exherin Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + SCH 727965 DCU4FCV SCH 727965 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
NVP-AUY922 + SCH 727965 DC3HLYS SCH 727965 Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + THAPSIGARGIN DCAHWRZ THAPSIGARGIN Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Biperiden DC0PU39 Biperiden DD2 (Cell Line: DD2) [3]
NVP-AUY922 + Mifepristone DCVX44S Mifepristone Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
NVP-AUY922 + Mitomycin DCXFWJS Mitomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
NVP-AUY922 + Mitomycin DCK4H0K Mitomycin Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + OSI-906 DCSD8H7 OSI-906 Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + SNX-5422 DCVUQLF SNX-5422 Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Ciclopirox DCGNHKJ Ciclopirox Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
NVP-AUY922 + ABT-263 DCU6LHC ABT-263 Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Bardoxolone methyl DCKHGOS Bardoxolone methyl Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Ispinesib DC7MLR1 Ispinesib Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + (-)-englerin A DCF4U0X (-)-englerin A Ewing sarcoma (Cell Line: TC-71) [3]
NVP-AUY922 + Pyronaridine DC5H2B9 Pyronaridine DD2 (Cell Line: DD2) [3]
NVP-AUY922 + Vinpocetine DCL8U80 Vinpocetine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
NVP-AUY922 + Auranofin DC7OUGB Auranofin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
NVP-AUY922 + Atovaquone DC6TCVC Atovaquone DD2 (Cell Line: DD2) [3]
NVP-AUY922 + Ruxolitinib DCJI23E Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [4]
NVP-AUY922 + Panobinostat DC3KBP0 Panobinostat Hepatoblastoma (Cell Line: HB3) [4]
NVP-AUY922 + BIX-01294 DCQH7NC BIX-01294 Hepatoblastoma (Cell Line: HB3) [4]
NVP-AUY922 + Alvespimycin hydrochloride DC5LVBA Alvespimycin hydrochloride Hepatoblastoma (Cell Line: HB3) [4]
NVP-AUY922 + Artemisinin DCEQS4M Artemisinin Hepatoblastoma (Cell Line: HB3) [4]
PHA-739358 + NVP-AUY922 DCN1BL7 PHA-739358 Ewing sarcoma (Cell Line: TC-71) [3]
Proguanil + NVP-AUY922 DCOXPYX Proguanil Hepatoblastoma (Cell Line: HB3) [3]
RTB101 + NVP-AUY922 DCT9EFX RTB101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
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⏷ Show the Full List of 53 DrugCom(s)

References

1 ClinicalTrials.gov (NCT01854034) Phase 2 Study of AUY922 in NSCLC Patients With Exon 20 Insertion Mutations in EGFR. U.S. National Institutes of Health.
2 Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027019)
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.