Details of the Drug Combinations

General Information of This Drug (ID: DMU10FE)

Drug Name
THZ1   DMU10FE
Synonyms HY-80013
Indication
Disease Entry ICD 11 Status REF
Nasopharyngeal carcinoma 2B6B Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

24 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ABT-199 + THZ1 DC4BWMZ ABT-199 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
BMS-754807 + THZ1 DC3OL0T BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Buparlisib + THZ1 DCCATEQ Buparlisib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
DZNep + THZ1 DCNOQJQ DZNep Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Erlotinib + THZ1 DC3D6F3 Erlotinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Evacetrapib + THZ1 DC2M0UY Evacetrapib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Everolimus + THZ1 DC7M0WS Everolimus Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Lenalidomide + THZ1 DCQZBVG Lenalidomide Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
MK-2206 + THZ1 DCK2K3X MK-2206 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
ONC201 + THZ1 DCS27ZC ONC201 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PHA848125 + THZ1 DCIMDPG PHA848125 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
RTB101 + THZ1 DCHFGO8 RTB101 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + Buparlisib DCKWFF1 Buparlisib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + JQ1 DC4E95Q JQ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + Carfilzomib DCB7CY2 Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + Panobinostat DC131CB Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + Abexinostat DC3CMCA Abexinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + CA4P DCNI4FE CA4P Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + Marizomib DCBHCKW Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + SNDX-275 DCYY6UL SNDX-275 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + BMS-754807 DCN6XA4 BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + Citarinostat DC1A7Z3 Citarinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THZ1 + PF-562271 DC8BXG8 PF-562271 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Venglustat + THZ1 DCRLSFX Venglustat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
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⏷ Show the Full List of 24 DrugCom(s)

References

1 Super-Enhancers Promote Transcriptional Dysregulation in Nasopharyngeal Carcinoma.Cancer Res. 2017 Dec 1;77(23):6614-6626.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.