Details of the Drug Combinations

General Information of This Drug (ID: DMUDIR8)

• Drug Name: Fludrocortisone (DMUDIR8)
• Synonyms: fludrocortisone; Fluorocortisone; Fluorocortisol; Fluohydrisone; Florinef; Fluohydrocortisone; Astonin-H; Fludrocortone; Alflorone; Fludronef; Fludrone; Fluodrocortisone; 127-31-1; F-Cortef; 9alpha-Fluorocortisol; Fludrocortisona; Fludrocortisonum; F-COL; 9-Fluorocortisol; 9 alpha FF; 9-Fluorohydrocortisone; Cortisol, 9-fluoro-; StC 1400; 9alpha-Fludrocortisone; 9-AFH; 9-alpha-Fluorocortisol; 9-alpha-Fludrocortisone; Fludrocortisonum [INN-Latin]; Fludrocortisona [INN-Spanish]; 9-AF; Alflorone; Astonin; FCOL; Astonin H; Astonin Merck; Merck Brand of Fludrocortisone; U 5963; ZK5; F-Cortef;Florinef (TN); Fludrocortisone (INN); Fludrocortisone [INN:BAN]; Merck, Astonin; Astonin-H (TN); Hydrocortisone-9alpha-fluoro; Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-(8CI); (11beta)-9-Fluoro-11,17,21-trihydroxypregn-4-ene-3,20-dione; (8S,9R,10S,11S,13S,14S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-1,2,6,7,8,11,12,14,15,16-decahydrocyclopenta[a]phenanthren-3-one; 9 Fluoro 17 Hydroxycortisone; 9 Fluorocortisol; 9 Fluorohydrocortisone; 9 alpha Fludrohydrocortisone; 9 alpha Fluoro 17 Hydroxycorticosterone; 9 alpha Fluorohydrocortisone; 9 alpha-Fludrocortisone; 9 alpha-Fluoro-17-Hydroxycorticosterone; 9 alpha-Fluorocortisol; 9 alpha-Fluorohydrocortisone; 9-Fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9-Fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione; 9-Fluoro-17-Hydroxycortisone; 9-alpha-Fluoro-17-hydroxycorticosterone; 9-alpha-Fluorohydrocortisone; 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione; 9alpha-Fluoro-17-hydroxycorticosterone; 9alpha-Fluorohydrocortisone; 9alpha-Fluoro-hydrocortisone

Indication

Addison disease; ICD 11: 5A74.0; Status: Approved [1]; Cerebral salt-wasting syndrome; ICD 11: 5C72; Status: Approved [2]; Congenital adrenal hyperplasia; ICD 11: 5A71.01; Status: Approved [1]

• Therapeutic Class: Antiinflammatory Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Cycloserine + Fludrocortisone	DCCW82P	Cycloserine	Major Depression	[3]
Hydrocortisone + Fludrocortisone	DC55Y85	Hydrocortisone	Renin Angiotensin	[4]
Hydrocortisone + Fludrocortisone	DCJBBY2	Hydrocortisone	Septic Shock	[5]
Fludrocortisone + Bromocriptine	DCJK1VN	Bromocriptine	Ovarian Hyperstimulation Syndrome	[6]

References

• [1] Fludrocortisone FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2873).
• [3] ClinicalTrials.gov (NCT03062150) Mineralocorticoid Receptor, NMDA Receptor and Cognitive Function in Depression
• [4] ClinicalTrials.gov (NCT00673270) Effects of Fludrocortisone and Hydrocortisone in Healthy Volunteers With Aldosterone Induced Suppression
• [5] ClinicalTrials.gov (NCT00320099) Combination of Corticotherapy and Intensive Insulin Therapy for Septic Shock
• [6] ClinicalTrials.gov (NCT04351126) Management of Ovarian Hyperstimulation Syndrome as a State of Defective Mineralocorticoid Response