Details of the Drug Combinations

General Information of This Drug (ID: DMUL5EW)

• Drug Name: Posaconazole (DMUL5EW)
• Synonyms: Noxafil; Spriafil; Posaconazole SP; Posaconazole in combination with MGCD290; SCH56592; Sch 56592; X2N; Noxafil (TN); Noxafil, Posaconazole; SCH-56592; Posaconazole (USAN/INN); Posaconazole [USAN:INN:BAN]; 1-((1S,2S)-1-Ethyl-2-hydroxypropyl)-4-{4-[4-(4-{[(5S,3R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazolylmethyl)oxolan-3-yl]methoxy}phenyl)piperazinyl]phenyl}-1,2,4-triazolin-5-one; 4-(p-(4-(p-(((3R,5R)-5-(2,4-Difluorophenyl)tetrahydro-5-(1H-1,2,4-triazol-1-ylmethyl)-3-furyl)methoxy)phenyl)-1-piperazinyl)phenyl)-1-((1S,2S)-1-ethyl-2-hydroxypropyl)-delta(sup 2)-1,2,4-triazolin-5-one; 4-[4-[4-[4-[[(3R,5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one; 4-[4-[4-[4-[[(5R)-5-(2,4-difluorophenyl)-5-(1,2,4-triazol-1-ylmethyl)oxolan-3-yl]methoxy]phenyl]piperazin-1-yl]phenyl]-2-[(2S,3S)-2-hydroxypentan-3-yl]-1,2,4-triazol-3-one

Indication

Aspergillosis; ICD 11: 1F20; Status: Approved [1]; Candidiasis; ICD 11: 1F23; Status: Approved [2]; Chromomycosis; ICD 11: N.A.; Status: Approved [2]; Coccidioidomycosis; ICD 11: 1F25; Status: Approved [2]; Fusariosis; ICD 11: N.A.; Status: Approved [2]

• Therapeutic Class: Antifungal Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

2 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
F901318 + Posaconazole	DC5K5SB	F901318	Invasive Aspergillosis	[3]
Fluconazole + Posaconazole	DC3TZ23	Fluconazole	Candidiasis	[4]

References

• [1] FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 022003.
• [2] Posaconazole FDA Label
• [3] ClinicalTrials.gov (NCT03095547) Drug/Drug Interactions With F901318
• [4] ClinicalTrials.gov (NCT03828773) PTX3-targeted Antifungal Prophylaxis