Details of the Drug Combinations

General Information of This Drug (ID: DMUONK5)

Drug Name

amg-1 DMUONK5

Synonyms

CHEMBL3342402; N-(1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)[1,3]thiazolo[2,3-c][1,2,4]triazol-3-yl]sulfanyl}acetamide; BAS 06591295; AC1LLIU7; GTPL8227; SCHEMBL20313457; MolPort-000-220-791; ZINC801901; STL305655; BDBM50030791; AKOS000657540; MCULE-5294683561; ST50049773; Z56882059; N-(2H-1,3-benzodioxol-5-yl)-2-{[5-(4-methylphenyl)-[1,2,4]triazolo[3,4-b][1,3]thiazol-3-yl]sulfanyl}acetamide; 496023-55-3; N-(2H-benzo[3,4-d]1,3-dioxolen-5-yl)-2-[5-(4-methylphenyl)(1,3-thiazolino[3,2- d]1,2,4-triazol-3-ylthio)]acetamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Amg-1 + Marizomib	DCQKQK4	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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References

1	Purification and kinetic characterization of human indoleamine 2,3-dioxygenases 1 and 2 (IDO1 and IDO2) and discovery of selective IDO1 inhibitors. Biochim Biophys Acta. 2011 Dec;1814(12):1947-54.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.