Details of the Drug Combinations

General Information of This Drug (ID: DMUWAM2)

Drug Name
Pyronaridine   DMUWAM2
Synonyms
Malaridine; Pyronaridine phosphate salt; Benzonaphthyridine 7351; 2-Methoxy-7-chloro-10-(3',5'-bis(pyrrolin-1-ylmethyl)-4'-hydroxyphenylamino)benzo(b)-1,5-naphthyridine; 4-((7-Chloro-2-methoxybenzo(b)-1,5-naphthyridin-10-yl)amino)-2,6-bis(1-pyrrolidinylmethyl)phenol; 4-[(7-chloro-2-methoxy-1,5-dihydrobenzo[b][1,5]naphthyridin-10-yl)imino]-2,6-bis(pyrrolidin-1-ylmethyl)cyclohexa-2,5-dien-1-one; 4-[(7-chloro-2-methoxybenzo[b][1,5]naphthyridin-10-yl)amino]-2,6-bis(pyrrolidin-1-ylmethyl)phenol
Indication
Disease Entry ICD 11 Status REF
Malaria 1F40-1F45 Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

41 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Bafilomycin A1 + Pyronaridine DCX33QU Bafilomycin A1 DD2 (Cell Line: DD2) [2]
Berberine + Pyronaridine DCYXMYG Berberine DD2 (Cell Line: DD2) [2]
BGT226 + Pyronaridine DCCYUBA BGT226 DD2 (Cell Line: DD2) [2]
BGT226 + Pyronaridine DCG3M4Q BGT226 Hepatoblastoma (Cell Line: HB3) [3]
BHV-0223 + Pyronaridine DCTZF98 BHV-0223 DD2 (Cell Line: DD2) [2]
Biperiden + Pyronaridine DCPQ2S3 Biperiden Hepatoblastoma (Cell Line: HB3) [3]
Carfilzomib + Pyronaridine DC48KB8 Carfilzomib DD2 (Cell Line: DD2) [2]
Carfilzomib + Pyronaridine DCZCKBS Carfilzomib Hepatoblastoma (Cell Line: HB3) [2]
Clindamycin + Pyronaridine DC0AZA6 Clindamycin DD2 (Cell Line: DD2) [2]
Clindamycin + Pyronaridine DCCAVH8 Clindamycin Hepatoblastoma (Cell Line: HB3) [2]
Emetine + Pyronaridine DCUY36K Emetine DD2 (Cell Line: DD2) [2]
GDC-0077 + Pyronaridine DC4LXZ3 GDC-0077 DD2 (Cell Line: DD2) [2]
GSK2126458 + Pyronaridine DC07KHS GSK2126458 DD2 (Cell Line: DD2) [2]
Ivermectin + Pyronaridine DCG2ZSG Ivermectin Hepatoblastoma (Cell Line: HB3) [2]
Methotrexate + Pyronaridine DCVBDIJ Methotrexate DD2 (Cell Line: DD2) [2]
MK-4815 + Pyronaridine DC1KIOO MK-4815 DD2 (Cell Line: DD2) [2]
Naltrexone + Pyronaridine DCIOUWE Naltrexone Hepatoblastoma (Cell Line: HB3) [2]
NITD609 + Pyronaridine DCLMSRR NITD609 DD2 (Cell Line: DD2) [2]
NITD609 + Pyronaridine DCYYO8E NITD609 Hepatoblastoma (Cell Line: HB3) [3]
NVP-AUY922 + Pyronaridine DC5H2B9 NVP-AUY922 DD2 (Cell Line: DD2) [2]
Omacetaxine mepesuccinate + Pyronaridine DC96Z7O Omacetaxine mepesuccinate Hepatoblastoma (Cell Line: HB3) [3]
Panobinostat + Pyronaridine DCI7WOU Panobinostat DD2 (Cell Line: DD2) [2]
Pyronaridine + Lumefantrine DC56219 Lumefantrine DD2 (Cell Line: DD2) [2]
Pyronaridine + Artemether DC7U9JD Artemether DD2 (Cell Line: DD2) [2]
Pyronaridine + Artemisinin DCT18NE Artemisinin DD2 (Cell Line: DD2) [2]
Pyronaridine + Chloroquine DCEKACQ Chloroquine DD2 (Cell Line: DD2) [2]
Pyronaridine + Piperaquine DCK5TJ3 Piperaquine DD2 (Cell Line: DD2) [2]
Pyronaridine + Mefloquine DCC23NU Mefloquine DD2 (Cell Line: DD2) [2]
Pyronaridine + Atovaquone DC0J9I7 Atovaquone DD2 (Cell Line: DD2) [2]
Pyronaridine + Ruxolitinib DCAGCC8 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Pyronaridine + Epothilone B DCK4HEP Epothilone B Hepatoblastoma (Cell Line: HB3) [3]
Pyronaridine + Artemisinin DC4141M Artemisinin Hepatoblastoma (Cell Line: HB3) [3]
Pyronaridine + Mefloquine DCCW723 Mefloquine Hepatoblastoma (Cell Line: HB3) [3]
Pyronaridine + Atovaquone DCY8FO9 Atovaquone Hepatoblastoma (Cell Line: HB3) [3]
Safinamide mesylate + Pyronaridine DC2PJCR Safinamide mesylate Hepatoblastoma (Cell Line: HB3) [2]
Sorafenib + Pyronaridine DC3JRV6 Sorafenib DD2 (Cell Line: DD2) [2]
TG100-115 + Pyronaridine DCGS3LR TG100-115 Hepatoblastoma (Cell Line: HB3) [2]
Thiolactomycin + Pyronaridine DCO2XXP Thiolactomycin DD2 (Cell Line: DD2) [2]
Trichostatin A + Pyronaridine DCIQP1G Trichostatin A DD2 (Cell Line: DD2) [2]
Vorinostat + Pyronaridine DC5Z4BH Vorinostat Hepatoblastoma (Cell Line: HB3) [2]
VR-776 + Pyronaridine DCFYHFL VR-776 DD2 (Cell Line: DD2) [2]
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⏷ Show the Full List of 41 DrugCom(s)

References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.