Details of the Drug Combinations

General Information of This Drug (ID: DMVBPRO)

Drug Name

CP-673451 DMVBPRO

Synonyms

CP-673,451

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
CP-673451 + Panobinostat	DCKO7CV	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
CP-673451 + AS602868	DCCO2HG	AS602868	Hodgkin lymphoma (Cell Line: L-1236)	[2]
CP-673451 + BGT226	DCY22GY	BGT226	Hodgkin lymphoma (Cell Line: L-1236)	[2]
PMID25656651-Compound-5 + CP-673451	DCE5NQG	PMID25656651-Compound-5	Hodgkin lymphoma (Cell Line: L-1236)	[3]
Vincristine + CP-673451	DCI4B2L	Vincristine	Hodgkin lymphoma (Cell Line: L-1236)	[2]
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References

1	Antiangiogenic and antitumor activity of a selective PDGFR tyrosine kinase inhibitor, CP-673,451. Cancer Res. 2005 Feb 1;65(3):957-66.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.