Details of the Drug Combinations

General Information of This Drug (ID: DMVN2E6)

Drug Name
Vinpocetine   DMVN2E6
Synonyms
Bravinton; Cavinton; Ceractin; Vinpocetinum; Apovincaminic acid ethyl ester; AY 27255; RGH 4405; TCV 3B; V 6383; V6383_SIGMA; AY 27,255; Apovincaminate d'ethyle; Apovincaminate d'ethyle [French]; Cavinton (TN); Cis-Apovincaminic acid ethyl ester; Intelectol (TN); RGH-4405; TCV-3B; Ultra-Vinca; Vinpocetine-ethyl apovincaminate; Vinpocetinum [INN-Latin]; Eburnamenine-14-carboxylic acid ethyl ester; Ethyl apovincamin-22-oate; Vinpocetine [USAN:INN:JAN]; Ethyl (+)-apovincaminate; Vinpocetine (JAN/USAN/INN); Ethyl(+)-cis-apovincaminate; Ethyl apovincaminate, (3alpha,16alpha)-isomer; Ethyl (3alpha,16alpha)-eburnamenine-14-carboxylate; (+)-Apovincaminic acid ethyl ester; (+)-cis-Apovincaminic acid ethyl ester; (3alpha, 16alpha)-Eburnamenine-14-carboxylic acid ethyl ester; 1H-Indolo[3,2,1-de]pyrido[3,2,1-ij][1,5]naphthyridine, eburnamenine-14-carboxylic acid deriv.; 3-alpha,16-alpha-Apovincaminic acid ethyl ester
Indication
Disease Entry ICD 11 Status REF
Ischemic stroke 8B11.5Z Approved [1]
Therapeutic Class
Vasodilator Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

11 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Carfilzomib + Vinpocetine DCMN1XQ Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Chloroquine + Vinpocetine DC0TLWD Chloroquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Chloroxine + Vinpocetine DCR7YFJ Chloroxine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Dorsomorphin + Vinpocetine DC11E9A Dorsomorphin Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Gefitinib + Vinpocetine DCQU312 Gefitinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
MLN8237 + Vinpocetine DCY84XT MLN8237 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
NVP-AUY922 + Vinpocetine DCL8U80 NVP-AUY922 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
RTB101 + Vinpocetine DC6U2VI RTB101 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Tamoxifen + Vinpocetine DCZSBG1 Tamoxifen Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Trametinib + Vinpocetine DC7DCNY Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Vinpocetine + Piperaquine DCLZWE0 Piperaquine DD2 (Cell Line: DD2) [2]
------------------------------------------------------------------------------------
⏷ Show the Full List of 11 DrugCom(s)
1 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Aspirin + Vinpocetine DCACVBV Aspirin Stroke [4]
------------------------------------------------------------------------------------

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5285).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT02878772) Vinpocetine Inhibits NF-B-dependent Inflammation in Acute Ischemic Stroke Patients