Details of the Drug Combinations

General Information of This Drug (ID: DMVN5OH)

Drug Name
Minocycline   DMVN5OH
Synonyms
Borymycin; MINO; MIY; Minociclina; Minociclinum; Minocin; Minocline; Minocyclin; Minocyclinum; Minocycline Monohydrochloride; CL 59806; Lactoferrin B & Minocycline; Lactoferrin H & Minocycline; Minociclina [INN-Spanish]; Minocin (Hydrochloride); Minocin (TN); Minocyclinum [INN-Latin]; Vectrin (Hydrochloride); CRL-1605 & Minocycline; Minocycline (USAN/INN); Minocycline [USAN:BAN:INN]; (2Z,4S,4aS,5aR,12aS)-2-[amino(hydroxy)methylidene]-4,7-bis(dimethylamino)-10,11,12a-trihydroxy-4a,5,5a,6-tetrahydro-4H-tetracene-1,3,12-trione; (4S,4AS,5AR,12AS)-4,7-BIS(DIMETHYLAMINO)-3,10,12,12A-TETRAHYDROXY-1,11-DIOXO-1,4,4A,5,5A,6,11,12A-OCTAHYDROTETRACENE-2-CARBOXAMIDE; 4,7-Bis(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-2-naphthacenecarboxamide; 7-Dimethylamino-6-demethyl-6-deoxytetracycline
Indication
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [1]
Actinomycosis N.A. Approved [1]
Acute gonococcal cervicitis N.A. Approved [1]
Bacterial infection 1A00-1C4Z Approved [2]
Bartonellosis N.A. Approved [1]
Bronchitis CA20 Approved [1]
Brucellosis N.A. Approved [1]
Chancroid N.A. Approved [1]
Listeriosis N.A. Approved [1]
Lymphogranuloma venereum N.A. Approved [1]
Ornithosis N.A. Approved [1]
Periodontitis DA0C Approved [1]
Pneumonia CA40 Approved [1]
Q fever N.A. Approved [1]
Relapsing fever N.A. Approved [1]
Rickettsialpox N.A. Approved [1]
Rocky mountain spotted fever N.A. Approved [1]
Syphilis N.A. Approved [1]
Trachoma N.A. Approved [1]
Tularemia 1B94 Approved [1]
Typhus N.A. Approved [1]
Urinary tract infection GC08 Approved [1]
Yaws N.A. Approved [1]
Rosacea ED90.0 Phase 2 [3]
Plague N.A. Investigative [1]
Sinusitis CA0A.Z Investigative [1]
Vibrio cholerae infection 1A00 Investigative [1]
⏷ Show the Full List of Indication(s)
Therapeutic Class
Antibiotics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Minocycline + Idarubicin DCO95EJ Idarubicin Glioblastoma? (Cell Line: T98G) [4]
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10 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Amiodarone + Minocycline DCB8RLV Amiodarone Atrial Fibrillation [5]
Aspirin + Minocycline DC17BGU Aspirin Bipolar Disorder Depression [6]
Doxycycline + Minocycline DC5Z0HE Doxycycline Aneurysms [7]
Heparin + Minocycline DCPNBON Heparin Acute Ischemic Stroke [8]
Ketamine + Minocycline DCCUPIS Ketamine Depressive Disorder [9]
Mesalazine + Minocycline DC6QED9 Mesalazine Inflammatory Bowel Diseases [10]
Celecoxib + Minocycline DCZF4V3 Celecoxib Depression [11]
Azelaic Acid + Minocycline DCE35VL Azelaic Acid Rosacea [12]
Isotretinoin + Minocycline DCET9K3 Isotretinoin Acne Vulgaris [13]
Minocycline + Colistimethate DC0TCKI Colistimethate Acinetobacter Infections [14]
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⏷ Show the Full List of 10 DrugCom(s)

References

1 Minocycline FDA Label
2 Emerging disease-modifying therapies for the treatment of motor neuron disease/amyotropic lateral sclerosis. Expert Opin Emerg Drugs. 2007 May;12(2):229-52.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
5 ClinicalTrials.gov (NCT01422148) Minocycline Plus Amiodarone Versus Amiodarone Alone for the Prevention of Atrial Fibrillation After Cardiac Surgery
6 ClinicalTrials.gov (NCT01429272) Minocycline and Aspirin in the Treatment of Bipolar Depression
7 ClinicalTrials.gov (NCT00243893) Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
8 ClinicalTrials.gov (NCT00836355) Enoxaparin and/or Minocycline in Acute Stroke
9 ClinicalTrials.gov (NCT01809340) The Effect of Minocycline on Relapse After Successful Intravenous Ketamine/Minocycline-induced Symptoms Response in Subjects With Depression
10 ClinicalTrials.gov (NCT06201793) Minocyclin in Ulcerative Colitis as Added on Therapy
11 ClinicalTrials.gov (NCT02703363) Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression
12 ClinicalTrials.gov (NCT05014906) Efficacy of Oral Minocycline (Solodyn) and Oral Minocycline (Solodyn) Plus Azelaic Acid (Finacea) for Acne Rosacea
13 ClinicalTrials.gov (NCT04940767) A Companion Treatment Study for Patients With Moderate to Severe Acne Vulgaris
14 ClinicalTrials.gov (NCT05586815) Efficacy of Colistin Monotherapy Versus Colistin Plus Minocycline for Carbapenem-Resistant A. Baumannii Infection