General Information of This Drug (ID: DMW6F0S)

Drug Name
Mizoribine   DMW6F0S
Synonyms
Bredinin; Bredinine; MZR; Mizoribina; Mizoribinum; M 3047; Bredinin (TN); HE-69; HS-0046; Mizoribina [INN-Spanish]; Mizoribine [INN:JAN]; Mizoribinum [INN-Latin]; Mizoribine (JAN/INN); Bredinin, HE 69, NSC 289637, MZB, Mizoribine; Anhydro-4-carbamoyl-5-hydroxy-1-beta-D-ribofuranosyl-imidazolium hydroxide; N'-(beta-D-Ribofuranosyl)-5-hydroxyimidazole-4-carboxamide; N'-(beta-D-Ribofuranosyl)-5-hydroxy-imida-zole-4-carboxamide; 1-[(2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-hydroxyimidazole-4-carboxamide;4-Carbamoyl-1-beta-D-ribofuranosyl-imidazolium-5-olate; 4-carbamoyl-1-b-d-ribofuranosylimidazolium-5-olate; 5-Hydroxy-1-beta-D-ribofuranosyl-1H-imidazole-4-carboxamide; 5-Hydroxy-1-beta-D-ribofuranosylimidazole-4-carboxamide
Indication
Disease Entry ICD 11 Status REF
Transplant rejection NE84 Approved [1]
Therapeutic Class
Antimetabolites
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Colchicine + Mizoribine DCI01E1 Colchicine Lymphoid neoplasm (Cell Line: Mak) [2]
Mizoribine + DZNep DC6I55S DZNep Lymphoid neoplasm (Cell Line: Mak) [2]
Mizoribine + Panobinostat DC9JUBU Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Mizoribine + RG6046 DCS9IXJ RG6046 Lymphoid neoplasm (Cell Line: Mak) [2]
Mizoribine + Sunitinib malate DCZUKWW Sunitinib malate Lymphoid neoplasm (Cell Line: Mak) [2]
Ospemifene + Mizoribine DC44YZX Ospemifene Lymphoid neoplasm (Cell Line: Mak) [2]
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⏷ Show the Full List of 6 DrugCom(s)

References

1 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.