Details of the Drug Combinations

General Information of This Drug (ID: DMWC34B)

Drug Name

BAG956 DMWC34B

Synonyms

NVP-BAG956; 853910-02-8; BAG 956; NVP-BAG956(BAG 956); BAG-956; UNII-4UFC2K6E50; 4UFC2K6E50; 2-Methyl-2-(4-(2-methyl-8-((pyridin-3-yl)ethynyl)imidazo(4,5-C)quinolin-1-yl)phenyl)propionitrile; 2-methyl-2-(4-(2-methyl-8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl)phenyl)propanenitrile; BAG956; 2-Methyl-2-{4-[2-methyl-8-(pyridin-3-ylethynyl)-1H-imidazo[4,5-c]quinolin-1-yl]phenyl}propanenitrile; 2-Methyl-2-[4-[2-methyl-8-[(pyridin-3-yl)ethynyl]imidazo[4,5-c]quinolin-1-yl]phenyl]propionitrile; NVP-BAG-956

Indication

Disease Entry	ICD 11	Status	REF
Haematological malignancy	2B33.Y	Investigative	[1]
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Therapeutic Class

Anticancer Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
BAG956 + Ruxolitinib	DCRNGDH	Ruxolitinib	T-cell leukemia/lymphoma (Cell Line: ED-40515)	[2]
BAG956 + Panobinostat	DCLP3UJ	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
BAG956 + Mitomycin	DCCKRSI	Mitomycin	Diffuse large B cell lymphoma (Cell Line: TMD8)	[2]
BAG956 + Ruxolitinib	DCL3RAK	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
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References

1	The PI3K/Akt pathway as a target in the treatment of hematologic malignancies. Anticancer Agents Med Chem. 2009 Jun;9(5):550-9.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.