Details of the Drug Combinations

General Information of This Drug (ID: DMWSMND)

Drug Name
Cevimeline   DMWSMND
Synonyms
Evoxac; Saligren; Cevimeline [INN]; Cevimeline hydrochloride; Cevimeline hydrochloride [USAN]; Cevimeline hydrochloride hemihydrate; Cevimeline hydrochloride hydrate; AF 102B; AF102B; Fks 508; AF-102B; Cevimeline (INN); Cevimeline HCl 1/2H2O; Cevimeline hydrochloride (USAN); Cevimeline hydrochloride hydrate (JAN); Cevimeline.HCl; Evoxac (TN); FKS-508; SND-5008; SNI-2011; SNK-508; Saligren (TN); SND 5008, AF-102B, FKS-508; Cis-2-Methylspiro(1,3-oxathiolane-5,3')quinuclidine hydrochloride hydrate (2:2:1); (+-)-cis-2-Methylspiro(1,3-oxathiolane-5,3'-quinuclidine) hydrochloride, hemihydrate; (+/-)-cis-2-methylspiro(1-azabicyclo[2.2.2]octance-3,5'-(1,3)oxathiolane) hydrochloride hemihydrate; (2R,2'R)-2'-methylspiro[4-azabicyclo[2.2.2]octane-2,5'-[1,3]oxathiolane] dihydrochloride hydrate; (2R,5R)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane]; (2R,5R)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane] dihydrate hydrochloride; (2R,5R)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane] hydrate dihydrochloride; (2R,5R)-2-methylspiro[1,3-oxathiolane-5,3'-1-azabicyclo[2.2.2]octane] hydrate hydrochloride; 2-Methyspiro(1,3-oxathiolane-5,3)quinuclidine
Indication
Disease Entry ICD 11 Status REF
Sjogren syndrome 4A43.20 Approved [1]
Therapeutic Class
Parasympathomimetics
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

45 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acetohydroxamic Acid + Cevimeline DCMY4AM Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Cevimeline DCJTCRZ Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BRL-15572 + Cevimeline DC894UK BRL-15572 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Triiodothyronine DCP2H0N Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Gefitinib DCXG99I Gefitinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Imipramine DCS92ZS Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Terazosin DCSGLZX Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Tacrine DCWQNBI Tacrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Sivelestat DCT7PFD Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Guanfacine DCP9QQI Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Docetaxel DCBJN2I Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Galantamine DC3DUCK Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Dichlorphenamide DCVNCYF Dichlorphenamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + BIO-300 DC8943H BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + PF-02545920 DC2Q49T PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Tiagabine DCKNEIN Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Asenapine DCGC3IK Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Mycophenolic acid DCECNKR Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Doxorubicin DCYRUQR Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Auranofin DCBI4CW Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Vorinostat DCHVIHY Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + ML323 DCC4618 ML323 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Tacrolimus DCZYNJ3 Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Citalopram + Cevimeline DCELXU3 Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diazoxide + Cevimeline DCHP5IN Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Cevimeline DCWQRTS Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Estramustine + Cevimeline DCYQ06D Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GINKGOLIDE A + Cevimeline DC2Z8RE GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Cevimeline DCS94RJ GSK2194069 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Cevimeline DCT3KFD Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Cevimeline DCKMEBG IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + Cevimeline DCE3BWV Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Cevimeline DC6MZ9X Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maraviroc + Cevimeline DC6AXC2 Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mecamylamine + Cevimeline DC4AWGL Mecamylamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methotrexate + Cevimeline DC28KA0 Methotrexate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + Cevimeline DCPGJSJ Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + Cevimeline DCQXSHV Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Norcisapride + Cevimeline DCD0KUC Norcisapride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Oxyphenbutazone + Cevimeline DCOYTF9 Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Phensuximide + Cevimeline DCSCYQ2 Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pinacidil + Cevimeline DCA0C8P Pinacidil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Cevimeline DC1OKLA PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + Cevimeline DCDK472 Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + Cevimeline DCWUF4R Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 45 DrugCom(s)

References

1 Therapeutic effect of cevimeline on dry eye in patients with Sj gren's syndrome: a randomized, double-blind clinical study. Am J Ophthalmol. 2004 Jul;138(1):6-17.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.