Details of the Drug Combinations

General Information of This Drug (ID: DMXKDUL)

Drug Name

BGT226 DMXKDUL

Synonyms

BGT-226 free base; 915020-55-2; UNII-ZXE7F2GMJJ; BGT226 free base; ZXE7F2GMJJ; BGT-226; 8-(6-Methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-trifluoromethylphenyl]-1,3-dihydroimidazo[4,5-c]quinolin-2-one; CHEBI:71967; BGT 226; NVPBGT226; 8-(6-methoxypyridin-3-yl)-3-methyl-1-[4-(piperazin-1-yl)-3-(trifluoromethyl)phenyl]-1,3-dihydro-2H-imidazo[4,5-c]quinolin-2-one; 8-(6-Methoxy-pyridin-3-yl)-3-methyl-1-(4-piperazin-1-yl-3-trifluoromethyl-phenyl)-1,3-dihydro-imidazo[4,5-c]quinolin-2-one; NPV-BGT226; SCHEMBL146939

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
------------------------------------------------------------------------------------

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

27 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
10-hydroxycamptothecin + BGT226	DCPUOBH	10-hydroxycamptothecin	Hodgkin lymphoma (Cell Line: L-1236)	[2]
BGT226 + Clindamycin	DCFR6B5	Clindamycin	DD2 (Cell Line: DD2)	[3]
BGT226 + Panobinostat	DCLOHVT	Panobinostat	DD2 (Cell Line: DD2)	[3]
BGT226 + BIX-01294	DCDC56N	BIX-01294	DD2 (Cell Line: DD2)	[3]
BGT226 + Alvespimycin hydrochloride	DCCXF0J	Alvespimycin hydrochloride	DD2 (Cell Line: DD2)	[3]
BGT226 + Emetine	DCW67DS	Emetine	DD2 (Cell Line: DD2)	[3]
BGT226 + Marizomib	DCAOI2K	Marizomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[3]
BGT226 + Quinine	DC3X62K	Quinine	DD2 (Cell Line: DD2)	[3]
BGT226 + Piperaquine	DCE0WIV	Piperaquine	DD2 (Cell Line: DD2)	[3]
BGT226 + Pyronaridine	DCCYUBA	Pyronaridine	DD2 (Cell Line: DD2)	[3]
BGT226 + Mefloquine	DC8KOUU	Mefloquine	DD2 (Cell Line: DD2)	[3]
BGT226 + Atovaquone	DC9RKEG	Atovaquone	DD2 (Cell Line: DD2)	[3]
BGT226 + Clindamycin	DCIWZMI	Clindamycin	Hepatoblastoma (Cell Line: HB3)	[2]
BGT226 + Ruxolitinib	DCD51PE	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[2]
BGT226 + Carfilzomib	DCFALFV	Carfilzomib	Hepatoblastoma (Cell Line: HB3)	[2]
BGT226 + Panobinostat	DC05MX7	Panobinostat	Hepatoblastoma (Cell Line: HB3)	[2]
BGT226 + Tranylcypromine	DC6QNO3	Tranylcypromine	Hepatoblastoma (Cell Line: HB3)	[2]
BGT226 + Quinine	DCJK4W7	Quinine	Hepatoblastoma (Cell Line: HB3)	[2]
BGT226 + Piperaquine	DCHCEBF	Piperaquine	Hepatoblastoma (Cell Line: HB3)	[2]
BGT226 + Pyronaridine	DCG3M4Q	Pyronaridine	Hepatoblastoma (Cell Line: HB3)	[2]
Bleomycin + BGT226	DCFIYB7	Bleomycin	Hodgkin lymphoma (Cell Line: L-1236)	[2]
Bortezomib + BGT226	DCPD5QX	Bortezomib	Hodgkin lymphoma (Cell Line: L-1236)	[3]
CP-673451 + BGT226	DCY22GY	CP-673451	Hodgkin lymphoma (Cell Line: L-1236)	[3]
Fludarabine + BGT226	DCD846Y	Fludarabine	Hodgkin lymphoma (Cell Line: L-1236)	[2]
GDC-0084 + BGT226	DCI67ZQ	GDC-0084	Hodgkin lymphoma (Cell Line: L-1236)	[2]
Mitomycin + BGT226	DCD3J1R	Mitomycin	Hodgkin lymphoma (Cell Line: L-1236)	[2]
Vincristine + BGT226	DCBK8UV	Vincristine	Hodgkin lymphoma (Cell Line: L-1236)	[3]
------------------------------------------------------------------------------------


⏷ Show the Full List of 27 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7951).
2	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.