Details of the Drug Combinations

General Information of This Drug (ID: DMY2KX9)

Drug Name

Alendronate DMY2KX9

Synonyms

Arendal; Fosamax; ALENDRONATE SODIUM; ALENDRONIC ACID; Acide alendronique; Acido alendronico; Acidum alendronicum; MK 217; Acide alendronique [INN-French]; Acido alendronico [INN-Spanish]; Acidum alendronicum [INN-Latin]; Alendronic acid (INN); Alendronic acid [INN:BAN]; Bisphosphonate, 65; Fosamax (TN); MK-217; Phosphonic acid, (4-amino-1-hydroxybutylidene)bis; (4-Amino-1-hydroxybutylidene)bisphosphonic acid; (4-Amino-1-hydroxybutylidene)diphosphonic acid; (4-amino-1-hydroxy-1-phosphonobutyl)phosphonic acid; (4-amino-1-hydroxybutane-1,1-diyl)bis(phosphonic acid); 4-Amino-1-hydroxybutane-1,1-diphosphonate; 4-Amino-1-hydroxybutane-1,1-diphosphonic Acid; 4-Amino-1-hydroxybutylidene-1,1-bis(phosphonic acid); 4-Amino-1-hydroxybutylidene-1,1-bisphosphonate

Indication

Disease Entry	ICD 11	Status	REF
Bone Paget disease	N.A.	Approved	[1]
Exostosis	N.A.	Approved	[1]
Osteoporosis	FB83.0	Approved	[2]
Paget's disease	FB85	Approved	[2]
Prostate adenocarcinoma	N.A.	Approved	[1]
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Therapeutic Class

Bone Density Conservation Agents

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

6 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Teriparatide + Alendronate	DC25P1W	Teriparatide	Osteoporosis	[3]
Testosterone + Alendronate	DC7PHRC	Testosterone	Hypogonadism	[4]
Propranolol + Alendronate	DC4BOBC	Propranolol	Beta Blocker Toxicity	[5]
Cinacalcet + Alendronate	DCXXBNE	Cinacalcet	Hyperparathyroidism, Primary	[6]
Ibandronate + Alendronate	DC2KOB2	Ibandronate	Postmenopausal Osteoporosis	[7]
Tenofovir disoproxil + Alendronate	DC3CY1A	Tenofovir disoproxil	Bone Demineralization	[8]
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⏷ Show the Full List of 6 DrugCom(s)

References

1	Alendronate FDA Label
2	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3141).
3	ClinicalTrials.gov (NCT00000400) Alendronate and/or Parathyroid Hormone for Osteoporosis
4	ClinicalTrials.gov (NCT01460654) Testosterone and Alendronate in Hypogonadal Men
5	ClinicalTrials.gov (NCT04704947) Clinical Study Evaluating Beta Blockers Use and Fracture Risk in Patients With Primary Osteoporosis
6	ClinicalTrials.gov (NCT02417389) Efficacy of Cinacalcet in the Control of Primary Hyperparathyroidism
7	ClinicalTrials.gov (NCT02598440) A Study of Ibandronate (Bonviva) in Patients With Post-Menopausal Osteoporosis
8	ClinicalTrials.gov (NCT02322099) Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss