Details of the Drug Combinations

General Information of This Drug (ID: DMY8WDB)

Drug Name

CB3304 DMY8WDB

Synonyms

Noscapine

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 1/2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

10 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
BMS-754807 + CB3304	DCWDJJA	BMS-754807	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Carfilzomib + CB3304	DC78IZX	Carfilzomib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
CB3304 + Panobinostat	DCF58IT	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Doxorubicin + CB3304	DCGRKOY	Doxorubicin	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Gemcitabine + CB3304	DCERTL1	Gemcitabine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Larotrectinib + CB3304	DCQBFE0	Larotrectinib	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Methotrexate + CB3304	DCWKRYW	Methotrexate	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
PHA848125 + CB3304	DCDDNP7	PHA848125	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Prochlorperazine + CB3304	DCQBFVR	Prochlorperazine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
RTB101 + CB3304	DCZ9Z4K	RTB101	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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⏷ Show the Full List of 10 DrugCom(s)

References

1	ClinicalTrials.gov (NCT00912899) A Study of Noscapine HCl (CB3304 ) in Patients With Relapsed or Refractory Multiple Myeloma. U.S. National Institutes of Health.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.