Details of the Drug Combinations

General Information of This Drug (ID: DMY9BMK)

• Drug Name: Rocuronium (DMY9BMK)
• Synonyms: Esmeron (TN); Zemuron (TN); (2beta,3alpha,5alpha,16beta,17beta)-17-acetoxy-16-(1-allylpyrrolidinium-1-yl)-3-hydroxy-2-(morpholin-4-yl)androstane; [(2S,3S,5S,8R,9S,10S,13S,14S,16S,17R)-3-hydroxy-10,13-dimethyl-2-morpholin-4-yl-16-(1-prop-2-enylpyrrolidin-1-ium-1-yl)-2,3,4,5,6,7,8,9,11,12,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-17-yl] acetate

Indication

Muscle spasm; ICD 11: MB47.3; Status: Approved [1]

• Therapeutic Class: Neuromuscular Nondepolarizing Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

16 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
MK-8616 + Rocuronium	DCJVFOP	MK-8616	High-Frequency Jet Ventilation	[2]
Neostigmine + Rocuronium	DCH0D1S	Neostigmine	Anesthesia	[3]
Propofol + Rocuronium	DCP2SC9	Propofol	Muscle Relaxation	[4]
Rocuronium + Sevoflurane	DCEHBEX	Sevoflurane	Muscle Relaxation	[4]
Succinylcholine + Rocuronium	DCHUHWE	Succinylcholine	Neuromuscular Blockade	[5]
Thiopental + Rocuronium	DCIR270	Thiopental	Adverse Effect of Other General Anesthetics	[6]
Thiopental + Rocuronium	DCDQA9L	Thiopental	Adverse Effect of Other General Anesthetics	[6]
Magnesium Sulfate + Rocuronium	DCBNL1Z	Magnesium Sulfate	Muscle Relaxation	[7]
Propofol + Rocuronium	DCMBZUB	Propofol	Anesthesia	[8]
Rocuronium + Rocuronium	DCZOJRY	Rocuronium	Anesthesia	[8]
Esmolol + Rocuronium	DCQUXWV	Esmolol	Injection Site Irritation	[9]
Ketamine + Rocuronium	DCKCV4D	Ketamine	Inguinal Hernia	[10]
Neostigmine + Rocuronium	DCGD423	Neostigmine	Cirrhosis and Chronic Liver Disease	[11]
Propofol + Rocuronium	DC1WIT6	Propofol	Anesthesia	[12]
Propofol + Rocuronium	DCZL14Y	Propofol	Postoperative Confusion	[13]
Rocuronium + Sevoflurane	DCLTE3D	Sevoflurane	Muscle Relaxation Caused by Sevoflurane	[14]

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [2] ClinicalTrials.gov (NCT02888067) Surgical Conditions During Vocal Cord Surgery Requiring Jet Ventilation With Moderate vs. Deep Neuromuscular Block
• [3] ClinicalTrials.gov (NCT00675792) Comparison of Sugammadex Administered at 1-2 Post Tetanic Counts (PTCs) or Better With Neostigmine Administered as Per Standard of Care to Reverse Rocuronium-Induced Neuromuscular Blockade in Adults Undergoing Elective Open Abdominal Procedure (19.4.334) (P05774)
• [4] ClinicalTrials.gov (NCT00984633) Study of Efficacy, Pharmacokinetics, and Safety of Bolus Maintenance Doses of Org 9426 (Study P05976)(COMPLETED)
• [5] ClinicalTrials.gov (NCT01441960) Optimal Dose of Succinylcholine and Rocuronium for Electroconvulsive Therapy (ECT)
• [6] ClinicalTrials.gov (NCT02486926) The Effects of Remifentanil and Remifentanil-Alfentanil Administration in Children
• [7] ClinicalTrials.gov (NCT02669368) Magnesium Sulfate Effects on Onset and Duration of Low Dose Rocuronium in Patients Undergoing Laparoscopic Cholecystectomy
• [8] ClinicalTrials.gov (NCT00988520) Study of Efficacy, Pharmacokinetics and Safety of Continuous Intravenous Infusion of Org 9426 (Study P05977)
• [9] ClinicalTrials.gov (NCT01824758) Effect of Esmolol on Pain Due to Rocuronium
• [10] ClinicalTrials.gov (NCT02646709) The Effect of Different Dose of Ketamine With Low Dose Rocuronium in Children
• [11] ClinicalTrials.gov (NCT02414880) Sugammadex Versus Neostigmine in Patients With Liver Cirrhosis Undergoing Liver Resection
• [12] ClinicalTrials.gov (NCT02709473) The Effect of Propofol and Remifentanil Sequence on ED50 and ED95 of Rocuronium in Rapid Sequence Induction Anesthesia
• [13] ClinicalTrials.gov (NCT02631135) Cognitive Functions After TIVA With Dexmedetomidine
• [14] ClinicalTrials.gov (NCT02785653) Effect of Sevoflurane on the Onset Characteristics and Intubating Conditions of Rocuronium