Details of the Drug Combinations

General Information of This Drug (ID: DMYP3KI)

Drug Name

SINOMENINE DMYP3KI

Synonyms

Cucoline; Kukoline; (9alpha,13alpha,14alpha)-4-Hydroxy-3,7-dimethoxy-17-methyl-7,8-didehydromorphinan-6-one

Indication

Disease Entry	ICD 11	Status	REF
Arthritis	FA20	Discontinued in Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

2 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
SINOMENINE + Panobinostat	DCYV52O	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
SINOMENINE + Idarubicin	DCIALJ7	Idarubicin	Glioblastoma? (Cell Line: T98G)	[2]
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References

1	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800008290)
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.