Details of the Drug Combinations

General Information of This Drug (ID: DMZ2TD9)

Drug Name
GSK2194069   DMZ2TD9
Synonyms GSK-2194069; GSK 2194069
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

52 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Acamprosate + GSK2194069 DCT62NR Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Amiloride + GSK2194069 DC8LPUT Amiloride Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Azatadine + GSK2194069 DC52JEQ Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + GSK2194069 DCOZI6D Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + GSK2194069 DCOBJAY Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Busulfan + GSK2194069 DC4IA36 Busulfan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + GSK2194069 DCC7Y6X Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clopidogrel + GSK2194069 DCGIT1B Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Dantrolene + GSK2194069 DCCMKGS Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Darunavir + GSK2194069 DCXYJUI Darunavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Docetaxel + GSK2194069 DCL2IL6 Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Doxorubicin + GSK2194069 DCP8SA0 Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Emetine + GSK2194069 DC5MJ1O Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Aprepitant DCNX1YX Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Bepridil DCMNH0Q Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Diethylcarbamazine DCQDSAK Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Epinephrine DCQI1WC Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Fomepizole DCYECCZ Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Armodafinil DCTRLUN Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + PHA-739358 DCW61BS PHA-739358 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + PFK-158 DCF6B76 PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + BIO-300 DCP2VTL BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + GINKGOLIDE A DCMBL8D GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Fenoprofen DCUSDT7 Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Idarubicin DCKO6SN Idarubicin Glioblastoma? (Cell Line: T98G) [2]
GSK2194069 + Methylene blue DCXRWZ2 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Olanzapine DC43F4F Olanzapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Trimethobenzamide DCSSB7Z Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Brincidofovir DCTGKG3 Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Pomalidomide DCCUV9B Pomalidomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Spironolactone DCH6C4M Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Dextromethorphan DC31Y91 Dextromethorphan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Testolactone DC9FRM2 Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Auranofin DCWUPTJ Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Cevimeline DCS94RJ Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Guanfacine + GSK2194069 DCRV70W Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + GSK2194069 DC4VVK8 IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + GSK2194069 DC9BW3C Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lithium Citrate + GSK2194069 DCLHA99 Lithium Citrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + GSK2194069 DCVA66L Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mebendazole + GSK2194069 DCX7F6P Mebendazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metformin + GSK2194069 DC9MOMA Metformin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + GSK2194069 DCU4Q0K Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mycophenolic acid + GSK2194069 DCKLZ6N Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PF-02545920 + GSK2194069 DCE76DB PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + GSK2194069 DCLHLUJ PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pyrazinamide + GSK2194069 DCJKHZN Pyrazinamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Quinine + GSK2194069 DCF33E3 Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tiagabine + GSK2194069 DCCK9MO Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trihexyphenidyl + GSK2194069 DCIWW9L Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trioxsalen + GSK2194069 DC9A7LA Trioxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + GSK2194069 DC6ZZNT Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 52 DrugCom(s)

References

1 A human fatty acid synthase inhibitor binds beta-ketoacyl reductase in the keto-substrate site. Nat Chem Biol. 2014 Sep;10(9):774-9.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.