Details of the Drug Combinations

General Information of This Drug (ID: DMZD0NA)

Drug Name

torin 1 DMZD0NA

Synonyms

Torin-1

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]
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Drug Type

Small molecular drug

Structure

3D MOL is unavailable

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

5 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Torin 1 + Ruxolitinib	DCOL0ZB	Ruxolitinib	T-cell leukemia/lymphoma (Cell Line: ED-40515)	[2]
Torin 1 + Panobinostat	DC1OWU2	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
Torin 1 + PD-0173955	DCBUO5G	PD-0173955	DD2 (Cell Line: DD2)	[2]
Torin 1 + Quinine	DCP2ZLW	Quinine	DD2 (Cell Line: DD2)	[2]
Torin 1 + ZSTK474	DCAVKY1	ZSTK474	DD2 (Cell Line: DD2)	[2]
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References

1	An ATP-competitive mammalian target of rapamycin inhibitor reveals rapamycin-resistant functions of mTORC1. J Biol Chem. 2009 Mar 20;284(12):8023-32.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.