Details of the Drug Combinations

General Information of This Drug (ID: DMZJVR5)

Drug Name

ATI-17000 DMZJVR5

Synonyms

CompB; J-113397; UNII-00M5444DIY; CHEMBL357076; 00M5444DIY; J113397; 1-[(3R,4R)-1-(cyclooctylmethyl)-3-(hydroxymethyl)piperidin-4-yl]-3-ethylbenzimidazol-2-one; 1-[(3R,4R)-1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl]-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one; AC1NSK6N; J-113,397; 1-(1-cyclooctylmethyl-3-hydroxymethyl-4-piperidyl)-3-ethyl-1,3-dihydro-2H-benzimidazol-2-one; 256640-45-6; SCHEMBL875219; J 113397; GTPL1691; (+)-J-113397; ZINC1483900; BDBM50083230; NCGC00344513-02; 2H-Benzimidazol-2-one,

Indication

Disease Entry	ICD 11	Status	REF
Irritable bowel syndrome	DD91.0	Preclinical	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

4 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
ATI-17000 + JQ1	DCAV5CD	JQ1	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
ATI-17000 + Gemcitabine	DCYV04Q	Gemcitabine	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
ATI-17000 + PF-562271	DCTHF06	PF-562271	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
ATI-17000 + E7820	DC2LRXO	E7820	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
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References

1	Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.