Details of the Drug Formulations

General Information of Drug (ID: DM053KT)

Drug Name
Aprepitant Drug Info
Synonyms
Aprepitant [USAN]; L 754030; MK 0869; Emend (TN); L-754030; MK-0869; ONO-7436; Aprepitant (JAN/USAN/INN); MK-869, L-754030, Emend, Aprepitant; 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-Delta(2)-1,2,4-triazolin-5-one; 3-(((2R,3S)-3-(p-Fluorophenyl)-2-(((alphaR)-alpha-methyl-3,5-bis(trifluoromethyl)benzyl)oxy)morpholino)methyl)-delta(sup 2)-1,2,4-triazolin-5-one; 5-[[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; 5-[[(2S,3R)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl]-1,2-dihydro-1,2,4-triazol-3-one; 5-{[(2R,3S)-2-{(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}-3-(4-fluorophenyl)morpholin-4-yl]methyl}-2,4-dihydro-3H-1,2,4-triazol-3-one
Indication
Disease Entry ICD 11 Status REF
Depression 6A70-6A7Z Approved [1]
Nausea MD90 Approved [2]
Vomiting MD90 Approved [3]
Solid tumour/cancer 2A00-2F9Z Phase 3 [4]
Therapeutic Class
Antiemetics
Cross-matching ID
PubChem CID
135413536
ChEBI ID
CHEBI:499361
CAS Number
170729-80-3
TTD ID
D0GU4K
VARIDT ID
DR01398
INTEDE ID
DR0125
ACDINA ID
D00042

Full List of Drug Formulations Containing This Drug

Aprepitant 125 mg capsule
Company Formulation ID FDA Description
Glenmark Pharmaceutials F01373 Sodium lauryl sulfate; Sodium stearyl fumarate; Mannitol; Ferrosoferric oxide; Potassium hydroxide; Titanium dioxide; Water; Fd&c red no. 3; Poloxamer 407; Silicon dioxide; Tocophersolan; Gelatin, unspecified; Hydroxyethyl cellulose (140 mpa.s at 5%); Microcrystalline cellulose; Povidone, unspecified; Shellac
Sandoz F01372 Sodium lauryl sulfate; Fd&c blue no. 1; Ferrosoferric oxide; Propylene glycol; Sucrose; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Hydroxypropyl cellulose (type h); Shellac
Merck Sharp & Dohme F01374 Sodium lauryl sulfate; Ferric oxide red; Ferric oxide yellow; Sucrose; Titanium dioxide; Silicon dioxide; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Microcrystalline cellulose
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Aprepitant 40 mg capsule
Company Formulation ID FDA Description
Glenmark Pharmaceutials F01376 Sodium lauryl sulfate; Sodium stearyl fumarate; Mannitol; Ferric oxide yellow; Ferrosoferric oxide; Potassium hydroxide; Titanium dioxide; Water; Poloxamer 407; Silicon dioxide; Tocophersolan; Gelatin, unspecified; Hydroxyethyl cellulose (140 mpa.s at 5%); Microcrystalline cellulose; Povidone, unspecified; Shellac
Sandoz F01375 Sodium lauryl sulfate; Ferrosoferric oxide; Propylene glycol; Sucrose; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Hydroxypropyl cellulose (type h); Shellac
Rebel Distributors F01377 Sodium lauryl sulfate; Ferric oxide yellow; Sucrose; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Gelatin; Hydroxypropyl cellulose
Merck Sharp & Dohme F01378 Sodium lauryl sulfate; Ferric oxide yellow; Sucrose; Titanium dioxide; Silicon dioxide; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Microcrystalline cellulose
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Aprepitant 80 mg capsule
Company Formulation ID FDA Description
Glenmark Pharmaceutials F01380 Sodium lauryl sulfate; Sodium stearyl fumarate; Mannitol; Ferrosoferric oxide; Potassium hydroxide; Titanium dioxide; Water; Poloxamer 407; Silicon dioxide; Tocophersolan; Gelatin, unspecified; Hydroxyethyl cellulose (140 mpa.s at 5%); Microcrystalline cellulose; Povidone, unspecified; Shellac
Sandoz F01379 Sodium lauryl sulfate; Ferrosoferric oxide; Propylene glycol; Sucrose; Titanium dioxide; Cellulose, microcrystalline; Gelatin; Hydroxypropyl cellulose (type h); Shellac
Physicians Total Care F01381 Sodium lauryl sulfate; Sucrose; Titanium dioxide; Silicon dioxide; Cellulose, microcrystalline; Gelatin; Hydroxypropyl cellulose
Merck Sharp & Dohme F01382 Sodium lauryl sulfate; Sucrose; Titanium dioxide; Silicon dioxide; Gelatin, unspecified; Hydroxypropyl cellulose (1200000 mw); Microcrystalline cellulose
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References

1 Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3490).
3 Aprepitant FDA Label
4 ClinicalTrials.gov (NCT00571168) Efficacy and Safety of Aprepitant in Subjects With Multiple Myeloma During and After High-dose Chemotherapy. U.S. National Institutes of Health.