Details of the Drug Formulations

General Information of Drug (ID: DMBESUA)

• Drug Name: Tucatinib Drug Info
• Synonyms: Irbinitinib; 937263-43-9; ONT-380; UNII-234248D0HH; 234248D0HH; N6-(4,4-Dimethyl-4,5-dihydrooxazol-2-yl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)quinazoline-4,6-diamine; 4,6-Quinazolinediamine, N6-(4,5-dihydro-4,4-dimethyl-2-oxazolyl)-N4-(3-methyl-4-((1,2,4)triazolo(1,5-a)pyridin-7-yloxy)phenyl)-; ONT 380; 4,6-QuinazolinediaMine, N6-(4,5-dihydro-4,4-diMethyl-2-oxazolyl)-N4-[3-Methyl-4-([1,2,4]triazolo[1,5-a]pyridin-7-yloxy)phenyl]-; Tucatinib [USAN:INN]; 6-DIAMINE

Indication

Disease Entry	ICD 11	Status	REF
HER2-positive breast cancer	2C60-2C65	Approved	[1]
Gastric adenocarcinoma	2B72	Phase 2/3	[2]

• Cross-matching ID:
  PubChem CID: 51039094
  CAS Number: 937263-43-9
  TTD ID: D09GRX
  ACDINA ID: D01510

Full List of Drug Formulations Containing This Drug

Tucatinib 50 mg tablet

Company	Formulation ID	FDA Description
Seattle Genetics	F23924	Copovidone; Crospovidone; Sodium Chloride; Potassium Chloride; Sodium Bicarbonate; Colloidal Silicon Dioxide; Magnesium Stearate; Microcrystalline Cellulose; Polyvinyl Alcohol; Titanium Dioxide; Macrogol/Polyethylene Glycol; Talc; Yellow Iron Oxide Non-Irradiated

Tucatinib 150 mg tablet

Company	Formulation ID	FDA Description
Seattle Genetics	F23925	Copovidone; Crospovidone; Sodium Chloride; Potassium Chloride; Sodium Bicarbonate; Colloidal Silicon Dioxide; Magnesium Stearate; Microcrystalline Cellulose; Polyvinyl Alcohol; Titanium Dioxide; Macrogol/Polyethylene Glycol; Talc; Yellow Iron Oxide Non-Irradiated

References

• [1] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health Human Services. 2020
• [2] ClinicalTrials.gov (NCT04499924) Tucatinib, Trastuzumab, Ramucirumab, and Paclitaxel Versus Paclitaxel and Ramucirumab in Previously Treated HER2+ Gastroesophageal Cancer (MOUNTAINEER-02). U.S. National Institutes of Health.